ID   O167_CONST              Reviewed;          37 AA.
AC   P0C832;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Omega-conotoxin-like S6.7;
DE   Flags: Precursor; Fragment;
OS   Conus striatus (Striated cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=6493;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16183187; DOI=10.1016/j.biochi.2005.08.001;
RA   Pi C., Liu Y., Peng C., Jiang X., Liu J., Xu B., Yu X., Yu Y., Jiang X.,
RA   Wang L., Dong M., Chen S., Xu A.-L.;
RT   "Analysis of expressed sequence tags from the venom ducts of Conus
RT   striatus: focusing on the expression profile of conotoxins.";
RL   Biochimie 88:131-140(2006).
CC   -!- FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and
CC       block voltage-gated calcium channels (Cav). This toxin blocks N-,
CC       P- and Q-type calcium channels (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0C832; -.
DR   ConoServer; 3545; S6.7 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Amidation; Calcium channel impairing toxin; Disulfide bond;
KW   Ion channel impairing toxin; Knottin; Neurotoxin; Presynaptic neurotoxin;
KW   Secreted; Toxin; Voltage-gated calcium channel impairing toxin.
FT   PROPEP          <1..4
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000345104"
FT   PEPTIDE         5..37
FT                   /note="Omega-conotoxin-like S6.7"
FT                   /id="PRO_0000345105"
FT   DISULFID        5..20
FT                   /evidence="ECO:0000250"
FT   DISULFID        12..23
FT                   /evidence="ECO:0000250"
FT   DISULFID        19..32
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   37 AA;  3912 MW;  1D8C6D81021B9BB6 CRC64;
     KSTSCMEAGS YCGSTTRICC GYCAYSASKN VCDYPSN