ARR18_ARATH
ID ARR18_ARATH Reviewed; 635 AA.
AC Q9FGT7; F4KDI4;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Two-component response regulator ARR18;
GN Name=ARR18; OrderedLocusNames=At5g58080; ORFNames=K21L19.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=15173562; DOI=10.1104/pp.103.038109;
RA Mason M.G., Li J., Mathews D.E., Kieber J.J., Schaller G.E.;
RT "Type-B response regulators display overlapping expression patterns in
RT Arabidopsis.";
RL Plant Physiol. 135:927-937(2004).
CC -!- FUNCTION: Transcriptional activator that binds specifically to the DNA
CC sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in
CC His-to-Asp phosphorelay signal transduction system. Phosphorylation of
CC the Asp residue in the receiver domain activates the ability of the
CC protein to promote the transcription of target genes. Could directly
CC activate some type-A response regulators in response to cytokinins (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds the target DNA as a monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in young leaf tissue
CC developing anthers, and siliques. {ECO:0000269|PubMed:15173562}.
CC -!- PTM: Two-component system major event consists of a His-to-Asp
CC phosphorelay between a sensor histidine kinase (HK) and a response
CC regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC additional intermediate named Histidine-containing phosphotransfer
CC protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC Asp sequential transfer of a phosphate group between first an His and
CC an Asp of the HK protein, followed by the transfer to a conserved His
CC of the HPt protein and finally the transfer to an Asp in the receiver
CC domain of the RR protein.
CC -!- SIMILARITY: Belongs to the ARR family. Type-B subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB10999.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB024029; BAB10999.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED96995.2; -; Genomic_DNA.
DR RefSeq; NP_200616.4; NM_125193.4.
DR AlphaFoldDB; Q9FGT7; -.
DR SMR; Q9FGT7; -.
DR BioGRID; 21164; 4.
DR STRING; 3702.AT5G58080.1; -.
DR PaxDb; Q9FGT7; -.
DR PRIDE; Q9FGT7; -.
DR ProteomicsDB; 246931; -.
DR EnsemblPlants; AT5G58080.1; AT5G58080.1; AT5G58080.
DR GeneID; 835920; -.
DR Gramene; AT5G58080.1; AT5G58080.1; AT5G58080.
DR KEGG; ath:AT5G58080; -.
DR Araport; AT5G58080; -.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_024359_0_0_1; -.
DR InParanoid; Q9FGT7; -.
DR OMA; DIMNEMM; -.
DR OrthoDB; 291977at2759; -.
DR PhylomeDB; Q9FGT7; -.
DR PRO; PR:Q9FGT7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FGT7; baseline and differential.
DR Genevisible; Q9FGT7; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR InterPro; IPR045279; ARR-like.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR006447; Myb_dom_plants.
DR InterPro; IPR017053; Response_reg_B-typ_pln.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43874; PTHR43874; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PIRSF; PIRSF036392; RR_ARR_type-B; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 2: Evidence at transcript level;
KW Activator; Cytokinin signaling pathway; DNA-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1..635
FT /note="Two-component response regulator ARR18"
FT /id="PRO_0000132300"
FT DOMAIN 19..133
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 196..246
FT /note="Myb-like GARP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 144..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 193..196
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 153..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..184
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 70
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 635 AA; 70407 MW; D93852AF7093E268 CRC64;
MEFGSTEDGR HDKFPVGMRV LAVDDNPTCL RKLEELLLRC KYHVTKTMES RKALEMLREN
SNMFDLVISD VEMPDTDGFK LLEIGLEMDL PVIMLSAHSD YDSVMKGIIH GACDYLVKPV
GLKELQNIWH HVVKKNIKSY AKLLPPSESD SVPSASRKRK DKVNDSGDED DSDREEDDGE
GSEQDGDGSG TRKKPRVVWS QELHQKFVSA VQQLGLDKAV PKKILDLMSI EGLTRENVAS
HLQKYRLYLK KIDEGQQQNM TPDAFGTRDS SYFQMAQLDG LRDFTAARQI PSSGLLSRSH
LTKLQPPMYS SINLQGMNSS SFIQQGHHQN SSNSANPFGT YHSTLSPRIQ NVNLFQRTSS
PLEPLQFPRS KSYIGDFKGL GDRAIGGSFL DTCMPFGSSS TSLPSASTNP LMLQANYTQP
LHIASDGIQP CIEGTPSNSA SPNISFQGLS RFPGHSWQGN LNTTRFPPSS LPLNLAFLPD
QVTCAGNNLG DCTSLVSAEN PGGEMQCDPQ LLGGFMQNVN PLGGQKWEQQ NCTMLNNPFG
NIEYPLPADN MVFRDNNSTR SKGLDESLMN PIDNSQEYVG KATTMLDPEM KSGKPENDNQ
HDVFDDIMNE MMKQEENNGM VPVATRFGFD SFPPP
