ARR19_ARATH
ID ARR19_ARATH Reviewed; 407 AA.
AC Q9M9B9; F4I1N9; F4I1P0;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Putative two-component response regulator ARR19;
GN Name=ARR19; OrderedLocusNames=At1g49190; ORFNames=F27J15.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=15173562; DOI=10.1104/pp.103.038109;
RA Mason M.G., Li J., Mathews D.E., Kieber J.J., Schaller G.E.;
RT "Type-B response regulators display overlapping expression patterns in
RT Arabidopsis.";
RL Plant Physiol. 135:927-937(2004).
CC -!- FUNCTION: Putative transcriptional activator that binds specifically to
CC the DNA sequence 5'-[AG]GATT-3'. Functions as response regulator
CC involved in His-to-Asp phosphorelay signal transduction system.
CC Phosphorylation of the Asp residue in the receiver domain activates the
CC ability of the protein to promote the transcription of target genes.
CC Could directly activate some type-A response regulators in response to
CC cytokinins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds the target DNA as a monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9M9B9-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Detected in trichomes and siliques.
CC {ECO:0000269|PubMed:15173562}.
CC -!- PTM: Two-component system major event consists of a His-to-Asp
CC phosphorelay between a sensor histidine kinase (HK) and a response
CC regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC additional intermediate named Histidine-containing phosphotransfer
CC protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC Asp sequential transfer of a phosphate group between first an His and
CC an Asp of the HK protein, followed by the transfer to a conserved His
CC of the HPt protein and finally the transfer to an Asp in the receiver
CC domain of the RR protein.
CC -!- SIMILARITY: Belongs to the ARR family. Type-B subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF69721.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AEE32403.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC016041; AAF69721.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE32402.2; -; Genomic_DNA.
DR EMBL; CP002684; AEE32403.1; ALT_SEQ; Genomic_DNA.
DR PIR; F96528; F96528.
DR RefSeq; NP_001185179.1; NM_001198250.1.
DR RefSeq; NP_001319180.1; NM_001333372.1. [Q9M9B9-1]
DR AlphaFoldDB; Q9M9B9; -.
DR SMR; Q9M9B9; -.
DR PaxDb; Q9M9B9; -.
DR PRIDE; Q9M9B9; -.
DR EnsemblPlants; AT1G49190.1; AT1G49190.1; AT1G49190. [Q9M9B9-1]
DR GeneID; 841342; -.
DR Gramene; AT1G49190.1; AT1G49190.1; AT1G49190. [Q9M9B9-1]
DR KEGG; ath:AT1G49190; -.
DR Araport; AT1G49190; -.
DR TAIR; locus:2028476; AT1G49190.
DR eggNOG; KOG1601; Eukaryota.
DR InParanoid; Q9M9B9; -.
DR OMA; NGYLAMN; -.
DR OrthoDB; 767773at2759; -.
DR PRO; PR:Q9M9B9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9M9B9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000156; F:phosphorelay response regulator activity; ISS:TAIR.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; TAS:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR InterPro; IPR045279; ARR-like.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006447; Myb_dom_plants.
DR InterPro; IPR017053; Response_reg_B-typ_pln.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43874; PTHR43874; 2.
DR Pfam; PF00072; Response_reg; 1.
DR PIRSF; PIRSF036392; RR_ARR_type-B; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; Cytokinin signaling pathway; DNA-binding;
KW Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1..407
FT /note="Putative two-component response regulator ARR19"
FT /id="PRO_0000132301"
FT DOMAIN 35..150
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 217..271
FT /note="Myb-like GARP"
FT MOTIF 214..217
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOD_RES 86
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 407 AA; 46155 MW; DF61FA382B79D5D2 CRC64;
MLVGKISGYE DNTRSLERET SEITSLLSQF PGNTNVLVVD TNFTTLLNMK QIMKQYAYQV
SIETDAEKAL AFLTSCKHEI NIVIWDFHMP GIDGLQALKS ITSKLDLPVV IMSDDNQTES
VMKATFYGAC DYVVKPVKEE VMANIWQHIV RKRLIFKPDV APPKPRMTWS EVFQPVQSHL
VPTDGLDRDH FDSITINGGN GIQNMEKKQG KKPRKPRMTW TEELHQKFLE AIEIIGGIEK
ANPKVLVECL QEMRIEGITR SNVASHLQKH RINLEENQIP QQTQGNGWAT AYGTLAPSLQ
GSDNVNTTIP SYLMNGPATL NQIQQNQYQN GFLTMNNNQI ITNPPPPLPY LDHHHQQQHQ
SSPQFNYLMN NEELLQASGL SATDLELTYP SLPYDPQEYL INGYNYN
