ID   O16A2_CONST             Reviewed;          72 AA.
AC   Q9XZL5;
DT   13-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Omega-conotoxin-like SVIA mutant 2;
DE   Flags: Precursor;
OS   Conus striatus (Striated cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=6493;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=10573284; DOI=10.1016/s0196-9781(99)00116-3;
RA   Lu B.-S., Yu F., Zhao D., Huang P.-T., Huang C.-F.;
RT   "Conopeptides from Conus striatus and Conus textile by cDNA cloning.";
RL   Peptides 20:1139-1144(1999).
CC   -!- FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and
CC       block voltage-gated calcium channels (Cav). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; AF146361; AAD31921.1; -; mRNA.
DR   AlphaFoldDB; Q9XZL5; -.
DR   SMR; Q9XZL5; -.
DR   ConoServer; 596; Conotoxin-15 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   InterPro; IPR012321; Conotoxin_omega-typ_CS.
DR   Pfam; PF02950; Conotoxin; 1.
DR   PROSITE; PS60004; OMEGA_CONOTOXIN; 1.
PE   2: Evidence at transcript level;
KW   Calcium channel impairing toxin; Disulfide bond; Hydroxylation;
KW   Ion channel impairing toxin; Knottin; Neurotoxin; Presynaptic neurotoxin;
KW   Secreted; Signal; Toxin; Voltage-gated calcium channel impairing toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..48
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000034930"
FT   PEPTIDE         49..72
FT                   /note="Omega-conotoxin-like SVIA mutant 2"
FT                   /id="PRO_0000034931"
FT   MOD_RES         55
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   DISULFID        49..63
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        62..71
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   72 AA;  7790 MW;  4A7E1124F0B7F061 CRC64;
     MKLTCMVIVA VLLLTACQLI TAEDSRGTQK HRTLRSTARR SKSELTTRCR PSGSPCGVTS
     ICCGRCSRGK CT