ID   O16A_CONAB              Reviewed;          74 AA.
AC   Q9TVY1; Q9UA76; Q9UA77; Q9UA78;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Conotoxin AbVIA;
DE   Flags: Precursor; Fragment;
OS   Conus abbreviatus (Abbreviated cone) (Miliariconus abbreviatus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Virroconus.
OX   NCBI_TaxID=100123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=10359796; DOI=10.1073/pnas.96.12.6820;
RA   Duda T.F. Jr., Palumbi S.R.;
RT   "Molecular genetics of ecological diversification: duplication and rapid
RT   evolution of toxin genes of the venomous gastropod Conus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:6820-6823(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=15306367; DOI=10.1098/rspb.2004.2708;
RA   Duda T.F. Jr., Palumbi S.R.;
RT   "Gene expression and feeding ecology: evolution of piscivory in the
RT   venomous gastropod genus Conus.";
RL   Proc. R. Soc. B 271:1165-1174(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; AF090041; AAD48294.1; -; mRNA.
DR   EMBL; AF090042; AAD48295.1; -; mRNA.
DR   EMBL; AF090043; AAD48296.1; -; mRNA.
DR   EMBL; AF090044; AAD48297.1; -; mRNA.
DR   EMBL; AF090045; AAD48298.1; -; mRNA.
DR   EMBL; AF090046; AAD48299.1; -; mRNA.
DR   EMBL; AF090047; AAD48300.1; -; mRNA.
DR   EMBL; AF090048; AAD48301.1; -; mRNA.
DR   EMBL; AF090050; AAD48303.1; -; mRNA.
DR   EMBL; AF090051; AAD48304.1; -; mRNA.
DR   EMBL; AF090052; AAD48305.1; -; mRNA.
DR   EMBL; AF090053; AAD48306.1; -; mRNA.
DR   EMBL; AF090054; AAD48307.1; -; mRNA.
DR   EMBL; AF090073; AAD48326.1; -; mRNA.
DR   AlphaFoldDB; Q9TVY1; -.
DR   ConoServer; 1016; ABVIA precursor.
DR   ConoServer; 1025; ABVIA precursor.
DR   ConoServer; 1026; ABVIA precursor.
DR   ConoServer; 1028; ABVIA precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          <1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..38
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000392110"
FT   PEPTIDE         39..73
FT                   /note="Conotoxin AbVIA"
FT                   /id="PRO_0000392111"
FT   MOD_RES         73
FT                   /note="Serine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        50..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..68
FT                   /evidence="ECO:0000250"
FT   CONFLICT        18
FT                   /note="V -> E (in Ref. 1 and 2; AAD48306)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        19
FT                   /note="T -> A (in Ref. 1 and 2; AAD48304)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        24
FT                   /note="E -> K (in Ref. 1 and 2; AAD48306)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        62
FT                   /note="S -> T (in Ref. 1 and 2; AAD48303)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   74 AA;  7905 MW;  584F66E2F5F421CA CRC64;
     VLIIAVLFLT ACQLTTAVTS SRGEQKHRAL RSTDKKFKVA LLCSPPGSYC FGPAACCSNF
     CSTLSDVCQE SWSG