ID   O16A_CONLG              Reviewed;          24 AA.
AC   P0DOZ0;
DT   12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=Conotoxin Lo6/7a {ECO:0000303|PubMed:27801785};
OS   Conasprella longurionis (Cone snail) (Conus longurionis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conasprella; Fusiconus.
OX   NCBI_TaxID=1077918;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT PRO-24, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, MASS SPECTROMETRY, AND SYNTHESIS.
RC   TISSUE=Venom;
RX   PubMed=27801785; DOI=10.3390/md14110199;
RA   Lebbe E.K., Ghequire M.G., Peigneur S., Mille B.G., Devi P.,
RA   Ravichandran S., Waelkens E., D'Souza L., De Mot R., Tytgat J.;
RT   "Novel conopeptides of largely unexplored indo Pacific Conus sp.";
RL   Mar. Drugs 14:199-216(2016).
CC   -!- FUNCTION: 1 uM of this toxin does not show any effect on voltage-gated
CC       sodium and potassium channels (PubMed:27801785). Shows a turbid zone of
CC       antibacterial activity against the Gram-positive strain Bacillus
CC       megaterium (ATCC13632), but does not show antibacterial activity
CC       against other Gram-positive bacteria, and on Gram-negative bacteria
CC       (PubMed:27801785). {ECO:0000269|PubMed:27801785}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27801785}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:27801785}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC       {ECO:0000250|UniProtKB:P0CH19}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=2583.0; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:27801785};
CC   -!- MISCELLANEOUS: Does not show effect on Nav1.1, Nav1.2, Nav1.3, Nav1.4,
CC       Nav1.5, Nav1.6, Nav1.7 (PubMed:27801785). Does not show effect on
CC       Kv1.1, Kv1.3, Kv1.4, Kv1.5, Kv1.6 and Kv3.1 (PubMed:27801785).
CC       {ECO:0000269|PubMed:27801785}.
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DR   AlphaFoldDB; P0DOZ0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Knottin; Secreted;
KW   Toxin.
FT   PEPTIDE         1..24
FT                   /note="Conotoxin Lo6/7a"
FT                   /evidence="ECO:0000269|PubMed:27801785"
FT                   /id="PRO_0000439362"
FT   MOD_RES         24
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000269|PubMed:27801785"
FT   DISULFID        3..11
FT                   /evidence="ECO:0000250"
FT   DISULFID        6..16
FT                   /evidence="ECO:0000250"
FT   DISULFID        10..21
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   24 AA;  2590 MW;  16F77A697FBD5331 CRC64;
     DQCSYCGIYC CPPKFCTSAG CRSP