O16A_CONLI
ID O16A_CONLI Reviewed; 72 AA.
AC Q9TVN1; Q9UAA2; Q9UAA3; Q9UAA4; Q9UAA5; Q9UAA7; Q9UAB0; Q9UAB1;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 56.
DE RecName: Full=Conotoxin LvVIA;
DE Flags: Precursor; Fragment;
OS Conus lividus (Livid cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lividoconus.
OX NCBI_TaxID=89426;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=10359796; DOI=10.1073/pnas.96.12.6820;
RA Duda T.F. Jr., Palumbi S.R.;
RT "Molecular genetics of ecological diversification: duplication and rapid
RT evolution of toxin genes of the venomous gastropod Conus.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:6820-6823(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=15306367; DOI=10.1098/rspb.2004.2708;
RA Duda T.F. Jr., Palumbi S.R.;
RT "Gene expression and feeding ecology: evolution of piscivory in the
RT venomous gastropod genus Conus.";
RL Proc. R. Soc. B 271:1165-1174(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR EMBL; AF089902; AAD48158.1; -; mRNA.
DR EMBL; AF089904; AAD48160.1; -; mRNA.
DR EMBL; AF089905; AAD48161.1; -; mRNA.
DR EMBL; AF089906; AAD48162.1; -; mRNA.
DR EMBL; AF089907; AAD48163.1; -; mRNA.
DR EMBL; AF089910; AAD48165.1; -; mRNA.
DR EMBL; AF089912; AAD48167.1; -; mRNA.
DR EMBL; AF089913; AAD48168.1; -; mRNA.
DR EMBL; AF089914; AAD48169.1; -; mRNA.
DR EMBL; AF089915; AAD48170.1; -; mRNA.
DR EMBL; AF089916; AAD48171.1; -; mRNA.
DR EMBL; AF089917; AAD48172.1; -; mRNA.
DR EMBL; AF089918; AAD48173.1; -; mRNA.
DR EMBL; AF089919; AAD48174.1; -; mRNA.
DR EMBL; AF089920; AAD48175.1; -; mRNA.
DR EMBL; AF089921; AAD48176.1; -; mRNA.
DR EMBL; AF089922; AAD48177.1; -; mRNA.
DR EMBL; AF089923; AAD48178.1; -; mRNA.
DR EMBL; AF089924; AAD48179.1; -; mRNA.
DR EMBL; AF089925; AAD48180.1; -; mRNA.
DR EMBL; AF089926; AAD48181.1; -; mRNA.
DR EMBL; AF089927; AAD48182.1; -; mRNA.
DR EMBL; AF089928; AAD48183.1; -; mRNA.
DR EMBL; AF089929; AAD48184.1; -; mRNA.
DR EMBL; AF089930; AAD48185.1; -; mRNA.
DR EMBL; AF089931; AAD48186.1; -; mRNA.
DR EMBL; AF089932; AAD48187.1; -; mRNA.
DR EMBL; AF089933; AAD48188.1; -; mRNA.
DR EMBL; AF089941; AAD48196.1; -; mRNA.
DR EMBL; AF089942; AAD48197.1; -; mRNA.
DR EMBL; AF089943; AAD48198.1; -; mRNA.
DR EMBL; AF089944; AAD48199.1; -; mRNA.
DR EMBL; AF089945; AAD48200.1; -; mRNA.
DR EMBL; AF089946; AAD48201.1; -; mRNA.
DR EMBL; AF089947; AAD48202.1; -; mRNA.
DR EMBL; AF089948; AAD48203.1; -; mRNA.
DR EMBL; AF089949; AAD48204.1; -; mRNA.
DR EMBL; AF089950; AAD48205.1; -; mRNA.
DR EMBL; AF089951; AAD48206.1; -; mRNA.
DR EMBL; AF089952; AAD48207.1; -; mRNA.
DR EMBL; AF089953; AAD48208.1; -; mRNA.
DR EMBL; AF089954; AAD48209.1; -; mRNA.
DR EMBL; AF089955; AAD48210.1; -; mRNA.
DR EMBL; AF089956; AAD48211.1; -; mRNA.
DR EMBL; AF089958; AAD48213.1; -; mRNA.
DR EMBL; AF089959; AAD48214.1; -; mRNA.
DR AlphaFoldDB; Q9TVN1; -.
DR SMR; Q9TVN1; -.
DR ConoServer; 880; LvVIA 1 precursor.
DR ConoServer; 882; LvVIA 1 precursor.
DR ConoServer; 883; LvVIA 1 precursor.
DR ConoServer; 889; LvVIA 1 precursor.
DR ConoServer; 929; LvVIA 1 precursor.
DR ConoServer; 933; LvVIA 1 precursor.
DR ConoServer; 936; LvVIA 1 precursor.
DR ConoServer; 932; LvVIA 2 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT SIGNAL <1..17
FT /evidence="ECO:0000255"
FT PROPEP 18..41
FT /evidence="ECO:0000250"
FT /id="PRO_0000392140"
FT PEPTIDE 43..72
FT /note="Conotoxin LvVIA"
FT /id="PRO_0000392141"
FT DISULFID 44..58
FT /evidence="ECO:0000250"
FT DISULFID 51..63
FT /evidence="ECO:0000250"
FT DISULFID 57..70
FT /evidence="ECO:0000250"
FT CONFLICT 4
FT /note="I -> V (in Ref. 1 and 2; AAD48214)"
FT /evidence="ECO:0000305"
FT CONFLICT 7
FT /note="L -> P (in Ref. 1 and 2; AAD48214)"
FT /evidence="ECO:0000305"
FT CONFLICT 11
FT /note="A -> D (in Ref. 1 and 2; AAD48161)"
FT /evidence="ECO:0000305"
FT CONFLICT 11
FT /note="A -> G (in Ref. 1 and 2; AAD48167)"
FT /evidence="ECO:0000305"
FT CONFLICT 12
FT /note="S -> G (in Ref. 1 and 2; AAD48214)"
FT /evidence="ECO:0000305"
FT CONFLICT 26
FT /note="Y -> N (in Ref. 1 and 2; AAD48160)"
FT /evidence="ECO:0000305"
FT CONFLICT 29
FT /note="A -> T (in Ref. 1 and 2; AAD48207)"
FT /evidence="ECO:0000305"
FT CONFLICT 42
FT /note="R -> G (in Ref. 1 and 2; AAD48207)"
FT /evidence="ECO:0000305"
FT CONFLICT 42
FT /note="R -> W (in Ref. 1 and 2; AAD48211)"
FT /evidence="ECO:0000305"
FT CONFLICT 64
FT /note="S -> T (in Ref. 1 and 2; AAD48210)"
FT /evidence="ECO:0000305"
FT NON_TER 1
SQ SEQUENCE 72 AA; 7984 MW; B2057DDC87553B8D CRC64;
VLIIAVLFLT ASELVTADYT RDKWQYRAAS LRDAMRNFRD TRTCSPAGEV CTSKSPCCTG
FLCSHIGGMC HH
