ID   O16A_CONRA              Reviewed;          27 AA.
AC   P58914;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   26-JUL-2002, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Omega-conotoxin RVIA;
OS   Conus radiatus (Rayed cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Phasmoconus.
OX   NCBI_TaxID=61198;
RN   [1]
RP   PROTEIN SEQUENCE, AND HYDROXYLATION AT PRO-4 AND PRO-7.
RA   Miljanich G.P., Bitner R.S., Bowersox S.S., Fox J.A., Valentino K.L.,
RA   Yamashiro D.H.;
RT   "Method of treating ischemia-related neuronal damage.";
RL   Patent number US5051403, 24-SEP-1991.
CC   -!- FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and
CC       block voltage-gated calcium channels (Cav).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P58914; -.
DR   SMR; P58914; -.
DR   ConoServer; 1728; RVIA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012321; Conotoxin_omega-typ_CS.
DR   PROSITE; PS60004; OMEGA_CONOTOXIN; 1.
PE   1: Evidence at protein level;
KW   Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW   Hydroxylation; Ion channel impairing toxin; Knottin; Neurotoxin;
KW   Presynaptic neurotoxin; Secreted; Toxin;
KW   Voltage-gated calcium channel impairing toxin.
FT   PEPTIDE         1..27
FT                   /note="Omega-conotoxin RVIA"
FT                   /id="PRO_0000044478"
FT   MOD_RES         4
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|Ref.1"
FT   MOD_RES         7
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|Ref.1"
FT   DISULFID        1..16
FT   DISULFID        8..19
FT   DISULFID        15..26
SQ   SEQUENCE   27 AA;  2887 MW;  F554C1F8A01A88AF CRC64;
     CKPPGSPCRV SSYNCCSSCK SYNKKCG