ID   O16B_CONLI              Reviewed;          71 AA.
AC   Q9TW08; Q9UAA0; Q9UAA1; Q9UAA6; Q9UAA8; Q9UAA9;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Conotoxin LvVIB;
DE   Flags: Precursor; Fragment;
OS   Conus lividus (Livid cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lividoconus.
OX   NCBI_TaxID=89426;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=10359796; DOI=10.1073/pnas.96.12.6820;
RA   Duda T.F. Jr., Palumbi S.R.;
RT   "Molecular genetics of ecological diversification: duplication and rapid
RT   evolution of toxin genes of the venomous gastropod Conus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:6820-6823(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=15306367; DOI=10.1098/rspb.2004.2708;
RA   Duda T.F. Jr., Palumbi S.R.;
RT   "Gene expression and feeding ecology: evolution of piscivory in the
RT   venomous gastropod genus Conus.";
RL   Proc. R. Soc. B 271:1165-1174(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF089908; AAD48164.1; -; mRNA.
DR   EMBL; AF089911; AAD48166.1; -; mRNA.
DR   EMBL; AF089934; AAD48189.1; -; mRNA.
DR   EMBL; AF089935; AAD48190.1; -; mRNA.
DR   EMBL; AF089936; AAD48191.1; -; mRNA.
DR   EMBL; AF089937; AAD48192.1; -; mRNA.
DR   EMBL; AF089938; AAD48193.1; -; mRNA.
DR   EMBL; AF089939; AAD48194.1; -; mRNA.
DR   EMBL; AF089940; AAD48195.1; -; mRNA.
DR   EMBL; AF089957; AAD48212.1; -; mRNA.
DR   EMBL; AF089960; AAD48215.1; -; mRNA.
DR   EMBL; AF089961; AAD48216.1; -; mRNA.
DR   EMBL; AF089962; AAD48217.1; -; mRNA.
DR   EMBL; AF089963; AAD48218.1; -; mRNA.
DR   EMBL; AF089964; AAD48219.1; -; mRNA.
DR   EMBL; AF089965; AAD48220.1; -; mRNA.
DR   EMBL; AF089966; AAD48221.1; -; mRNA.
DR   EMBL; AF089967; AAD48222.1; -; mRNA.
DR   EMBL; AF089968; AAD48223.1; -; mRNA.
DR   EMBL; AF089969; AAD48224.1; -; mRNA.
DR   EMBL; AF089970; AAD48225.1; -; mRNA.
DR   AlphaFoldDB; Q9TW08; -.
DR   SMR; Q9TW08; -.
DR   ConoServer; 886; LvVIA 3 precursor.
DR   ConoServer; 888; LvVIB 1 precursor.
DR   ConoServer; 911; LvVIB 1 precursor.
DR   ConoServer; 912; LvVIB 1 precursor.
DR   ConoServer; 946; LvVIB 1 precursor.
DR   ConoServer; 939; LvVIB 2 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          <1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..41
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000392142"
FT   PEPTIDE         43..71
FT                   /note="Conotoxin LvVIB"
FT                   /id="PRO_0000392143"
FT   DISULFID        43..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        50..62
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..69
FT                   /evidence="ECO:0000250"
FT   CONFLICT        2
FT                   /note="L -> V (in Ref. 1 and 2; AAD48166)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        7
FT                   /note="L -> P (in Ref. 1 and 2; AAD48224)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        8
FT                   /note="F -> S (in Ref. 1 and 2; AAD48189)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        52..53
FT                   /note="RH -> SK (in Ref. 1 and 2; AAD48164)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        63
FT                   /note="N -> S (in Ref. 1 and 2; AAD48164)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        71
FT                   /note="H -> P (in Ref. 1 and 2; AAD48217)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   71 AA;  7974 MW;  41BD86C910530E56 CRC64;
     VLIIAVLFLT ASELVTADYT RDKWQYRAAS LRDAMRNFRD TRCSPGGEVC TRHSPCCTGF
     LCNHIGGMCH H