ID   O16B_CONPB              Reviewed;          31 AA.
AC   P0DMA2;
DT   11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT   11-DEC-2013, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Conotoxin pc6b {ECO:0000303|PubMed:22776330};
OS   Conus pictus (Cone snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Sciteconus.
OX   NCBI_TaxID=1042615;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=22776330; DOI=10.1016/j.peptides.2012.07.002;
RA   Peigneur S., Van Der Haegen A., Moller C., Waelkens E., Diego-Garcia E.,
RA   Mari F., Naude R., Tytgat J.;
RT   "Unraveling the peptidome of the South African cone snails Conus pictus and
RT   Conus natalis.";
RL   Peptides 41:8-16(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22776330}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:22776330}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- MASS SPECTROMETRY: Mass=3311.1; Method=Electrospray;
CC       Note=monoisotopic.; Evidence={ECO:0000269|PubMed:22776330};
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0DMA2; -.
DR   ConoServer; 5860; Pc6b.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012321; Conotoxin_omega-typ_CS.
DR   PROSITE; PS60004; OMEGA_CONOTOXIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Knottin; Secreted; Toxin.
FT   PEPTIDE         1..31
FT                   /note="Conotoxin pc6b"
FT                   /evidence="ECO:0000269|PubMed:22776330"
FT                   /id="PRO_0000424799"
FT   DISULFID        2..20
FT                   /evidence="ECO:0000250"
FT   DISULFID        9..25
FT                   /evidence="ECO:0000250"
FT   DISULFID        19..29
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   31 AA;  3319 MW;  1CD35B356097A58E CRC64;
     TCLEIGEFCG KPMMVGSLCC SPGWCFFICV G