ID   O16B_CONTE              Reviewed;          27 AA.
AC   P24159;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Delta-conotoxin TxVIB {ECO:0000305};
DE   AltName: Full=TxIB {ECO:0000303|PubMed:1761058, ECO:0000303|PubMed:8261090};
OS   Conus textile (Cloth-of-gold cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=6494;
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RC   STRAIN=Neovicarius; TISSUE=Venom;
RX   PubMed=1761058; DOI=10.1111/j.1432-1033.1991.tb16412.x;
RA   Fainzilber M., Gordon D., Hasson A., Spira M.E., Zlotkin E.;
RT   "Mollusc-specific toxins from the venom of Conus textile neovicarius.";
RL   Eur. J. Biochem. 202:589-595(1991).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=8261090; DOI=10.1111/j.1460-9568.1993.tb00205.x;
RA   Hasson A., Fainzilber M., Gordon D., Zlotkin E., Spira M.E.;
RT   "Alteration of sodium currents by new peptide toxins from the venom of a
RT   molluscivorous Conus snail.";
RL   Eur. J. Neurosci. 5:56-64(1993).
CC   -!- FUNCTION: Delta-conotoxins bind to site 6 of voltage-gated sodium
CC       channels (Nav) and inhibit the inactivation process. Induces membrane
CC       depolarization and spontaneous repetitive firing of neurons.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1761058}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:1761058}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   PIR; S19619; S19619.
DR   AlphaFoldDB; P24159; -.
DR   SMR; P24159; -.
DR   ConoServer; 1553; TxVIB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012322; Conotoxin_d-typ_CS.
DR   PROSITE; PS60005; DELTA_CONOTOXIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Knottin; Neurotoxin; Secreted; Toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   PEPTIDE         1..27
FT                   /note="Delta-conotoxin TxVIB"
FT                   /evidence="ECO:0000269|PubMed:1761058"
FT                   /id="PRO_0000044473"
FT   DISULFID        2..17
FT                   /evidence="ECO:0000250"
FT   DISULFID        9..21
FT                   /evidence="ECO:0000250"
FT   DISULFID        16..26
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   27 AA;  3063 MW;  575FB17D775B5A9D CRC64;
     WCKQSGEMCN VLDQNCCDGY CIVFVCT