ID   O16B_CONVX              Reviewed;          88 AA.
AC   Q8IS41;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Conotoxin VxVIB;
DE   AltName: Full=Conotoxin vx6b;
DE   Flags: Precursor;
OS   Conus vexillum (Flag cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Rhizoconus.
OX   NCBI_TaxID=89431;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 53-88, FUNCTION, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=16457862; DOI=10.1016/j.toxicon.2005.12.007;
RA   Jiang H., Xu C.-Q., Wang C.-Z., Fan C.-X., Zhao T.-Y., Chen J.-S.,
RA   Chi C.-W.;
RT   "Two novel O-superfamily conotoxins from Conus vexillum.";
RL   Toxicon 47:425-436(2006).
CC   -!- FUNCTION: May act as a neurotoxin, but produces no obvious effect on
CC       ionic currents when tested on the mouse dorsal rooted ganglia (DRG).
CC       {ECO:0000269|PubMed:16457862}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- MASS SPECTROMETRY: Mass=3820.2; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16457862};
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; AY151285; AAN71750.1; -; mRNA.
DR   AlphaFoldDB; Q8IS41; -.
DR   SMR; Q8IS41; -.
DR   ConoServer; 821; VxVIB precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Knottin; Neurotoxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..52
FT                   /evidence="ECO:0000269|PubMed:16457862"
FT                   /id="PRO_0000234825"
FT   PEPTIDE         53..88
FT                   /note="Conotoxin VxVIB"
FT                   /id="PRO_0000234826"
FT   DISULFID        53..68
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..72
FT                   /evidence="ECO:0000250"
FT   DISULFID        67..81
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   88 AA;  9518 MW;  D1A742E665E51E25 CRC64;
     MNLACVLIVA VLFLTASQLA TAASYARDKQ EYPAVRSSDE MQDSEDLTLT KECTDDSQFC
     DPNDHDCCSG ECIDEGGRGV CAIVPEHV