O16C_CONAB
ID O16C_CONAB Reviewed; 70 AA.
AC Q9TVU1; Q9UA80; Q9UA81; Q9UA82; Q9UA84;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 56.
DE RecName: Full=Conotoxin AbVIC;
DE Flags: Precursor; Fragment;
OS Conus abbreviatus (Abbreviated cone) (Miliariconus abbreviatus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Virroconus.
OX NCBI_TaxID=100123;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=10359796; DOI=10.1073/pnas.96.12.6820;
RA Duda T.F. Jr., Palumbi S.R.;
RT "Molecular genetics of ecological diversification: duplication and rapid
RT evolution of toxin genes of the venomous gastropod Conus.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:6820-6823(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=15306367; DOI=10.1098/rspb.2004.2708;
RA Duda T.F. Jr., Palumbi S.R.;
RT "Gene expression and feeding ecology: evolution of piscivory in the
RT venomous gastropod genus Conus.";
RL Proc. R. Soc. B 271:1165-1174(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR EMBL; AF090008; AAD48262.1; -; mRNA.
DR EMBL; AF090009; AAD48263.1; -; mRNA.
DR EMBL; AF090010; AAD48264.1; -; mRNA.
DR EMBL; AF090011; AAD48265.1; -; mRNA.
DR EMBL; AF090012; AAD48266.1; -; mRNA.
DR EMBL; AF090013; AAD48267.1; -; mRNA.
DR EMBL; AF090014; AAD48268.1; -; mRNA.
DR EMBL; AF090015; AAD48269.1; -; mRNA.
DR EMBL; AF090016; AAD48270.1; -; mRNA.
DR EMBL; AF090017; AAD48271.1; -; mRNA.
DR EMBL; AF090018; AAD48272.1; -; mRNA.
DR EMBL; AF090019; AAD48273.1; -; mRNA.
DR EMBL; AF090020; AAD48274.1; -; mRNA.
DR EMBL; AF090021; AAD48275.1; -; mRNA.
DR EMBL; AF090022; AAD48276.1; -; mRNA.
DR EMBL; AF090023; AAD48277.1; -; mRNA.
DR EMBL; AF090024; AAD48278.1; -; mRNA.
DR EMBL; AF090025; AAD48279.1; -; mRNA.
DR EMBL; AF090026; AAD48280.1; -; mRNA.
DR EMBL; AF090027; AAD48281.1; -; mRNA.
DR EMBL; AF090028; AAD48282.1; -; mRNA.
DR EMBL; AF090029; AAD48283.1; -; mRNA.
DR EMBL; AF090030; AAD48284.1; -; mRNA.
DR EMBL; AF090031; AAD48285.1; -; mRNA.
DR EMBL; AF090032; AAD48286.1; -; mRNA.
DR EMBL; AF090033; AAD48287.1; -; mRNA.
DR EMBL; AF090036; AAD48289.1; -; mRNA.
DR EMBL; AF090037; AAD48290.1; -; mRNA.
DR EMBL; AF090038; AAD48291.1; -; mRNA.
DR EMBL; AF090039; AAD48292.1; -; mRNA.
DR EMBL; AF090040; AAD48293.1; -; mRNA.
DR AlphaFoldDB; Q9TVU1; -.
DR SMR; Q9TVU1; -.
DR ConoServer; 1009; ABVIC precursor.
DR ConoServer; 1012; ABVIC precursor.
DR ConoServer; 1013; ABVIC precursor.
DR ConoServer; 1015; ABVIC precursor.
DR ConoServer; 984; ABVIC precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT SIGNAL <1..17
FT /evidence="ECO:0000255"
FT PROPEP 18..41
FT /evidence="ECO:0000250"
FT /id="PRO_0000392114"
FT PEPTIDE 42..70
FT /note="Conotoxin AbVIC"
FT /id="PRO_0000392115"
FT REGION 19..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 43..57
FT /evidence="ECO:0000250"
FT DISULFID 50..61
FT /evidence="ECO:0000250"
FT DISULFID 56..68
FT /evidence="ECO:0000250"
FT CONFLICT 2
FT /note="L -> I (in Ref. 1 and 2; AAD48291)"
FT /evidence="ECO:0000305"
FT CONFLICT 3
FT /note="I -> V (in Ref. 1 and 2; AAD48287)"
FT /evidence="ECO:0000305"
FT CONFLICT 35
FT /note="K -> E (in Ref. 1 and 2; AAD48290)"
FT /evidence="ECO:0000305"
FT CONFLICT 43
FT /note="C -> R (in Ref. 1 and 2; AAD48293)"
FT /evidence="ECO:0000305"
FT NON_TER 1
SQ SEQUENCE 70 AA; 7260 MW; 83C03BFD413506EF CRC64;
VLIIAVLFLT ACQLTTAETS SRGKQKHRAL RSTDKNSKLT RGCTPPGGAC GGHAHCCSQS
CNILASTCNA