ID   O16C_CONCT              Reviewed;          26 AA.
AC   P58919;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   26-JUL-2002, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Omega-conotoxin CVIC;
OS   Conus catus (Cat cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=101291;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT CYS-26, SYNTHESIS, AND FUNCTION.
RC   TISSUE=Venom;
RX   PubMed=10938268; DOI=10.1074/jbc.m002252200;
RA   Lewis R.J., Nielsen K.J., Craik D.J., Loughnan M.L., Adams D.A.,
RA   Sharpe I.A., Luchian T., Adams D.J., Bond T., Thomas L., Jones A.,
RA   Matheson J.-L., Drinkwater R., Andrews P.R., Alewood P.F.;
RT   "Novel omega-conotoxins from Conus catus discriminate among neuronal
RT   calcium channel subtypes.";
RL   J. Biol. Chem. 275:35335-35344(2000).
CC   -!- FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and
CC       block voltage-gated calcium channels (Cav). This toxin blocks N-,
CC       P- and Q-type calcium channels. {ECO:0000269|PubMed:10938268}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P58919; -.
DR   SMR; P58919; -.
DR   ConoServer; 1725; CVIC.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012321; Conotoxin_omega-typ_CS.
DR   PROSITE; PS60004; OMEGA_CONOTOXIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Calcium channel impairing toxin; Direct protein sequencing;
KW   Disulfide bond; Ion channel impairing toxin; Knottin; Neurotoxin;
KW   Presynaptic neurotoxin; Secreted; Toxin;
KW   Voltage-gated calcium channel impairing toxin.
FT   PEPTIDE         1..26
FT                   /note="Omega-conotoxin CVIC"
FT                   /id="PRO_0000044483"
FT   MOD_RES         26
FT                   /note="Cysteine amide"
FT                   /evidence="ECO:0000269|PubMed:10938268"
FT   DISULFID        1..16
FT                   /evidence="ECO:0000250"
FT   DISULFID        8..20
FT                   /evidence="ECO:0000250"
FT   DISULFID        15..26
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   26 AA;  2790 MW;  56EFC382335C4A8B CRC64;
     CKGKGQSCSK LMYDCCTGSC SRRGKC