ID   O16C_CONLI              Reviewed;          69 AA.
AC   Q9TVF7; Q9UA97; Q9UA98; Q9UA99;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Conotoxin LvVIC;
DE   Flags: Precursor; Fragment;
OS   Conus lividus (Livid cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Lividoconus.
OX   NCBI_TaxID=89426;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=10359796; DOI=10.1073/pnas.96.12.6820;
RA   Duda T.F. Jr., Palumbi S.R.;
RT   "Molecular genetics of ecological diversification: duplication and rapid
RT   evolution of toxin genes of the venomous gastropod Conus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:6820-6823(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=15306367; DOI=10.1098/rspb.2004.2708;
RA   Duda T.F. Jr., Palumbi S.R.;
RT   "Gene expression and feeding ecology: evolution of piscivory in the
RT   venomous gastropod genus Conus.";
RL   Proc. R. Soc. B 271:1165-1174(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; AF089976; AAD48231.1; -; mRNA.
DR   EMBL; AF089977; AAD48232.1; -; mRNA.
DR   EMBL; AF089978; AAD48233.1; -; mRNA.
DR   EMBL; AF089979; AAD48234.1; -; mRNA.
DR   EMBL; AF089980; AAD48235.1; -; mRNA.
DR   EMBL; AF089981; AAD48236.1; -; mRNA.
DR   AlphaFoldDB; Q9TVF7; -.
DR   ConoServer; 954; LVVICa precursor.
DR   ConoServer; 956; LVVICa precursor.
DR   ConoServer; 953; LvVICb precursor.
DR   ConoServer; 958; LvVICb precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          <1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..40
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000392144"
FT   PEPTIDE         42..69
FT                   /note="Conotoxin LvVIC"
FT                   /id="PRO_0000392145"
FT   DISULFID        43..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        50..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..68
FT                   /evidence="ECO:0000250"
FT   CONFLICT        4
FT                   /note="I -> V (in Ref. 1 and 2; AAD48236)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        8
FT                   /note="F -> S (in Ref. 1 and 2; AAD48234)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        26
FT                   /note="R -> T (in Ref. 1 and 2; AAD48234)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        55
FT                   /note="D -> H (in Ref. 1 and 2; AAD48231/AAD48236)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   69 AA;  7861 MW;  FBA5B55256532F8F CRC64;
     VLIIAVLFLT ACQLTTAETY PRGQQRHHAL RSTDKNSKLT RGCTPRNGFC RYHSDCCSNF
     CHTWAIMCL