ID   O16C_CONPI              Reviewed;          24 AA.
AC   P0CH19;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Conotoxin pr6c {ECO:0000303|PubMed:20570703};
OS   Conus parius (Cone snail).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Phasmoconus.
OX   NCBI_TaxID=505247;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Venom;
RX   PubMed=20570703; DOI=10.1016/j.peptides.2010.05.020;
RA   Jimenez E.C., Olivera B.M.;
RT   "Divergent M- and O-superfamily peptides from venom of fish-hunting Conus
RT   parius.";
RL   Peptides 31:1678-1683(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20570703}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:20570703}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC   -!- PTM: The three Pro-12, Pro-13 and Pro-24 were found to be not
CC       hydroxylated. {ECO:0000269|PubMed:20570703}.
CC   -!- MASS SPECTROMETRY: Mass=2614.0; Method=MALDI; Note=Monoisotopic mass.;
CC       Evidence={ECO:0000269|PubMed:20570703};
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DR   AlphaFoldDB; P0CH19; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Knottin; Secreted; Toxin.
FT   PEPTIDE         1..24
FT                   /note="Conotoxin pr6c"
FT                   /evidence="ECO:0000269|PubMed:20570703"
FT                   /id="PRO_0000397117"
FT   DISULFID        3..11
FT                   /evidence="ECO:0000250"
FT   DISULFID        6..16
FT                   /evidence="ECO:0000250"
FT   DISULFID        10..21
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   24 AA;  2620 MW;  16F77A697AA56331 CRC64;
     DQCTYCGIYC CPPKFCTSSG CRSP