ARR21_ARATH
ID ARR21_ARATH Reviewed; 613 AA.
AC Q9LYP5; F4K6L2;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Putative two-component response regulator ARR21;
GN Name=ARR21; OrderedLocusNames=At5g07210; ORFNames=T28J14_150;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RA Horak J., Brzobohaty B., Lexa M.;
RT "Molecular and physiological characterisation of an insertion mutant in the
RT ARR21 putative response regulator gene from Arabidopsis thaliana.";
RL Plant Biol. 5:245-254(2003).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=15173562; DOI=10.1104/pp.103.038109;
RA Mason M.G., Li J., Mathews D.E., Kieber J.J., Schaller G.E.;
RT "Type-B response regulators display overlapping expression patterns in
RT Arabidopsis.";
RL Plant Physiol. 135:927-937(2004).
CC -!- FUNCTION: Putative transcriptional activator that binds specifically to
CC the DNA sequence 5'-[AG]GATT-3'. Functions as response regulator
CC involved in His-to-Asp phosphorelay signal transduction system.
CC Phosphorylation of the Asp residue in the receiver domain activates the
CC ability of the protein to promote the transcription of target genes.
CC Could directly activate some type-A response regulators in response to
CC cytokinins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds the target DNA as a monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Mainly expressed in siliques. Also found in
CC germinating seedlings, stems, flowers and roots, but not in rosette
CC leaves. {ECO:0000269|PubMed:15173562, ECO:0000269|Ref.3}.
CC -!- PTM: Two-component system major event consists of a His-to-Asp
CC phosphorelay between a sensor histidine kinase (HK) and a response
CC regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC additional intermediate named Histidine-containing phosphotransfer
CC protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC Asp sequential transfer of a phosphate group between first an His and
CC an Asp of the HK protein, followed by the transfer to a conserved His
CC of the HPt protein and finally the transfer to an Asp in the receiver
CC domain of the RR protein.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype. {ECO:0000269|Ref.3}.
CC -!- SIMILARITY: Belongs to the ARR family. Type-B subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AED91122.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB87277.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL163652; CAB87277.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED91122.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; ANM69560.1; -; Genomic_DNA.
DR PIR; T48492; T48492.
DR RefSeq; NP_001331229.1; NM_001342931.1.
DR RefSeq; NP_196338.1; NM_120803.1.
DR AlphaFoldDB; Q9LYP5; -.
DR SMR; Q9LYP5; -.
DR BioGRID; 15891; 1.
DR STRING; 3702.AT5G07210.1; -.
DR PaxDb; Q9LYP5; -.
DR PRIDE; Q9LYP5; -.
DR EnsemblPlants; AT5G07210.2; AT5G07210.2; AT5G07210.
DR GeneID; 830612; -.
DR Gramene; AT5G07210.2; AT5G07210.2; AT5G07210.
DR KEGG; ath:AT5G07210; -.
DR Araport; AT5G07210; -.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_387641_0_0_1; -.
DR InParanoid; Q9LYP5; -.
DR OMA; DTNKEHE; -.
DR OrthoDB; 617429at2759; -.
DR PRO; PR:Q9LYP5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LYP5; baseline.
DR Genevisible; Q9LYP5; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR InterPro; IPR045279; ARR-like.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR006447; Myb_dom_plants.
DR InterPro; IPR017053; Response_reg_B-typ_pln.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43874; PTHR43874; 2.
DR Pfam; PF00072; Response_reg; 1.
DR PIRSF; PIRSF036392; RR_ARR_type-B; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 2: Evidence at transcript level;
KW Activator; Cytokinin signaling pathway; DNA-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1..613
FT /note="Putative two-component response regulator ARR21"
FT /id="PRO_0000132303"
FT DOMAIN 17..131
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 224..274
FT /note="Myb-like GARP"
FT REGION 178..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 221..224
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 179..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 68
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 613 AA; 69383 MW; 81EFA1A9AD7854AF CRC64;
MASAQSFYNQ SSVLKINVMV VDDDHVFLDI MSRMLQHSKY RVIAVDDPKK ALSTLKIQRD
NIDLIITDYY MPGMNGLQLK KQITQEFGNL PVLVMSSDTN KEEESLSCGA MGFIPKPIHP
TDLTKIYQFA LSNKRNGKST LSTEQNHKDA DVSVPQQITL VPEQADVLKT KRKNCSFKSD
SRTVNSTNGS CVSTDGSRKN RKRKPNGGPS DDGESMSQPA KKKKIQWTDS LHDLFLQAIR
HIGLDKAVPK KILAFMSVPY LTRENVASHL QKYRIFLRRV AEQGLYSMLS DRGIDSMFRQ
THIKEPYFNY YTPSTSWYDT RLNNRSFYSK PVHGFGQSKL LSTTREPVCF NQMPYNYMNR
SSTYEPHRIG SGSNLTLPIQ SNLSFPNQPS QNEERRSFFE PPVMANKIAQ TSQVLGFGQL
GPSAISGHNF NNNMTSRYGS LIPSQPGPSH FSYGMQSFLN NENVTYNPQP PANATTQPNL
DELPQLENLN LYNDFGNTSE LPYNISNFQF DDNKHQQGEA DPTKFELPAA KFSTELNHED
DGDWTFVNIN QGQSNGETSN TIASPETNTP ILNINHNQNQ GQDVPEFNDW SFLDPQELVD
DDFMNSLFNN DMN
