ID   O16D_CONVX              Reviewed;          81 AA.
AC   Q7Z028;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Conotoxin A11GB;
DE   Flags: Precursor;
OS   Conus vexillum (Flag cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Rhizoconus.
OX   NCBI_TaxID=89431;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Luo S., Zhang B., Zhangsun D.;
RT   "A11GB conotoxin scaffold VI/VII precursor.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; AY316159; AAP74715.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q7Z028; -.
DR   SMR; Q7Z028; -.
DR   ConoServer; 826; A11GB precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..53
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000414933"
FT   PEPTIDE         55..81
FT                   /note="Conotoxin A11GB"
FT                   /id="PRO_0000414934"
FT   DISULFID        55..72
FT                   /evidence="ECO:0000250|UniProtKB:Q26443"
FT   DISULFID        62..76
FT                   /evidence="ECO:0000250|UniProtKB:Q26443"
FT   DISULFID        71..80
FT                   /evidence="ECO:0000250|UniProtKB:Q26443"
SQ   SEQUENCE   81 AA;  9037 MW;  A7C5D186914BA293 CRC64;
     MKLTCMMIVA VLFLTAWTVV TAEPHSSNVL ENLYLKAHHE MENPEASKLN TRDRCQRANF
     VCDAFHHAAV CCEGVCVLVC A