ID   O16E_CONCL              Reviewed;          97 AA.
AC   D2Y499; D6C4L0;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 2.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Conotoxin Cal6.1e {ECO:0000303|PubMed:21172372};
DE   AltName: Full=Conotoxin Cl6.3 {ECO:0000303|PubMed:20363338};
DE   Flags: Precursor;
OS   Californiconus californicus (California cone) (Conus californicus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Californiconus.
OX   NCBI_TaxID=1736779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=20363338; DOI=10.1016/j.ympev.2010.03.029;
RA   Biggs J.S., Watkins M., Puillandre N., Ownby J.P., Lopez-Vera E.,
RA   Christensen S., Moreno K.J., Bernaldez J., Licea-Navarro A., Corneli P.S.,
RA   Olivera B.M.;
RT   "Evolution of Conus peptide toxins: analysis of Conus californicus Reeve,
RT   1844.";
RL   Mol. Phylogenet. Evol. 56:1-12(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 63-97.
RC   TISSUE=Venom duct;
RX   PubMed=21172372; DOI=10.1016/j.toxicon.2010.12.008;
RA   Elliger C.A., Richmond T.A., Lebaric Z.N., Pierce N.T., Sweedler J.V.,
RA   Gilly W.F.;
RT   "Diversity of conotoxin types from Conus californicus reflects a diversity
RT   of prey types and a novel evolutionary history.";
RL   Toxicon 57:311-322(2011).
CC   -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC       channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:21172372}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:21172372}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; FJ959152; ADB93122.1; -; Genomic_DNA.
DR   EMBL; GU306164; ADB04242.1; -; mRNA.
DR   AlphaFoldDB; D2Y499; -.
DR   SMR; D2Y499; -.
DR   ConoServer; 3973; Cal6.1e precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..60
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_0000414973"
FT   PEPTIDE         63..97
FT                   /note="Conotoxin Cal6.1e"
FT                   /evidence="ECO:0000305|PubMed:21172372"
FT                   /id="PRO_5000566323"
FT   REGION          23..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        71..87
FT                   /evidence="ECO:0000250"
FT   DISULFID        78..91
FT                   /evidence="ECO:0000250"
FT   DISULFID        86..96
FT                   /evidence="ECO:0000250"
FT   CONFLICT        70
FT                   /note="G -> R (in Ref. 2; ADB04242)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   97 AA;  10448 MW;  F92AF0611319BAEB CRC64;
     MKLTTVLIVA VLVLAACQFT VTDNSGDDTE NPSLRSAGEN QNPDSTKTIT ARATRARTNM
     RRGLSRPSKG CIGGGDPCEF HRGYTCCSEH CIIWVCA