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ARR22_ARATH
ID   ARR22_ARATH             Reviewed;         142 AA.
AC   Q9M8Y4;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Two-component response regulator ARR22;
GN   Name=ARR22; OrderedLocusNames=At3g04280; ORFNames=T6K12.10;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION.
RX   PubMed=14973166; DOI=10.1105/tpc.018978;
RA   To J.P.C., Haberer G., Ferreira F.J., Deruere J., Mason M.G.,
RA   Schaller G.E., Alonso J.M., Ecker J.R., Kieber J.J.;
RT   "Type-A Arabidopsis response regulators are partially redundant negative
RT   regulators of cytokinin signaling.";
RL   Plant Cell 16:658-671(2004).
CC   -!- FUNCTION: Functions as response regulator involved in His-to-Asp
CC       phosphorelay signal transduction system. Phosphorylation of the Asp
CC       residue in the receiver domain activates the ability of the protein to
CC       promote the transcription of target genes. Type-A response regulators
CC       seem to act as negative regulators of the cytokinin signaling (By
CC       similarity). {ECO:0000250, ECO:0000269|PubMed:14973166}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- PTM: Two-component system major event consists of a His-to-Asp
CC       phosphorelay between a sensor histidine kinase (HK) and a response
CC       regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC       additional intermediate named Histidine-containing phosphotransfer
CC       protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC       Asp sequential transfer of a phosphate group between first an His and
CC       an Asp of the HK protein, followed by the transfer to a conserved His
CC       of the HPt protein and finally the transfer to an Asp in the receiver
CC       domain of the RR protein.
CC   -!- SIMILARITY: Belongs to the ARR family. Type-A subfamily. {ECO:0000305}.
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DR   EMBL; AC016829; AAF26786.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE74060.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE74061.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE74062.1; -; Genomic_DNA.
DR   EMBL; AY085638; AAM62859.1; -; mRNA.
DR   RefSeq; NP_001078102.1; NM_001084633.1.
DR   RefSeq; NP_187078.1; NM_111299.3.
DR   RefSeq; NP_850511.1; NM_180180.3.
DR   AlphaFoldDB; Q9M8Y4; -.
DR   SMR; Q9M8Y4; -.
DR   BioGRID; 4918; 3.
DR   STRING; 3702.AT3G04280.1; -.
DR   PaxDb; Q9M8Y4; -.
DR   PRIDE; Q9M8Y4; -.
DR   ProteomicsDB; 246899; -.
DR   EnsemblPlants; AT3G04280.1; AT3G04280.1; AT3G04280.
DR   EnsemblPlants; AT3G04280.2; AT3G04280.2; AT3G04280.
DR   EnsemblPlants; AT3G04280.3; AT3G04280.3; AT3G04280.
DR   GeneID; 819583; -.
DR   Gramene; AT3G04280.1; AT3G04280.1; AT3G04280.
DR   Gramene; AT3G04280.2; AT3G04280.2; AT3G04280.
DR   Gramene; AT3G04280.3; AT3G04280.3; AT3G04280.
DR   KEGG; ath:AT3G04280; -.
DR   Araport; AT3G04280; -.
DR   TAIR; locus:2102960; AT3G04280.
DR   eggNOG; KOG0519; Eukaryota.
DR   HOGENOM; CLU_000445_69_12_1; -.
DR   InParanoid; Q9M8Y4; -.
DR   OMA; FHCETTL; -.
DR   OrthoDB; 1546032at2759; -.
DR   PhylomeDB; Q9M8Y4; -.
DR   PRO; PR:Q9M8Y4; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9M8Y4; baseline and differential.
DR   Genevisible; Q9M8Y4; AT.
DR   GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; ISS:TAIR.
DR   GO; GO:0101006; F:protein histidine phosphatase activity; IDA:TAIR.
DR   GO; GO:0009736; P:cytokinin-activated signaling pathway; IMP:TAIR.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IC:TAIR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   2: Evidence at transcript level;
KW   Cytokinin signaling pathway; Nucleus; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..142
FT                   /note="Two-component response regulator ARR22"
FT                   /id="PRO_0000081434"
FT   DOMAIN          23..140
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   MOD_RES         74
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   142 AA;  15792 MW;  57487135FF2D5238 CRC64;
     MATKSTGGTE KTKSIEVKKK LINVLIVDDD PLNRRLHEMI IKTIGGISQT AKNGEEAVIL
     HRDGEASFDL ILMDKEMPER DGVSTTKKLR EMKVTSMIVG VTSVADQEEE RKAFMEAGLN
     HCLEKPLTKA KIFPLISHLF DA
 
 
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