ID   O16F_CONEA              Reviewed;          26 AA.
AC   C7T1P4;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Conotoxin Eb6.15;
DE   Flags: Fragment;
GN   Name=E1;
OS   Conus ebraeus (Hebrew cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Virroconus.
OX   NCBI_TaxID=89425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Okinawa; TISSUE=Foot;
RX   PubMed=19606224; DOI=10.1371/journal.pone.0006245;
RA   Duda T.F. Jr., Chang D., Lewis B.D., Lee T.;
RT   "Geographic variation in venom allelic composition and diets of the
RT   widespread predatory marine gastropod Conus ebraeus.";
RL   PLoS ONE 4:E6245-E6245(2009).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- MISCELLANEOUS: This peptide corresponds to allele E1l. Has not been
CC       merged with other alleles since they may differ due to geographic
CC       variation (see strain in PubMed:19606224).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; FJ834436; ACU56815.1; -; Genomic_DNA.
DR   AlphaFoldDB; C7T1P4; -.
DR   SMR; C7T1P4; -.
DR   ConoServer; 3837; Eb6.15 (Partial).
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Secreted; Toxin.
FT   PEPTIDE         <1..26
FT                   /note="Conotoxin Eb6.15"
FT                   /id="PRO_0000414640"
FT   DISULFID        7..18
FT                   /evidence="ECO:0000250"
FT   DISULFID        13..25
FT                   /evidence="ECO:0000250"
FT   DISULFID        ?..14
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   26 AA;  2669 MW;  4ECEE699C194D559 CRC64;
     TRSGGACNSH NQCCDDFCST ATSTCV