O16G_CONAB
ID O16G_CONAB Reviewed; 71 AA.
AC Q9TVX4; Q9UA87; Q9UA88; Q9UA89; Q9UA90;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 55.
DE RecName: Full=Conotoxin AbVIG;
DE Flags: Precursor; Fragment;
OS Conus abbreviatus (Abbreviated cone) (Miliariconus abbreviatus).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Virroconus.
OX NCBI_TaxID=100123;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=10359796; DOI=10.1073/pnas.96.12.6820;
RA Duda T.F. Jr., Palumbi S.R.;
RT "Molecular genetics of ecological diversification: duplication and rapid
RT evolution of toxin genes of the venomous gastropod Conus.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:6820-6823(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=15306367; DOI=10.1098/rspb.2004.2708;
RA Duda T.F. Jr., Palumbi S.R.;
RT "Gene expression and feeding ecology: evolution of piscivory in the
RT venomous gastropod genus Conus.";
RL Proc. R. Soc. B 271:1165-1174(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR EMBL; AF089997; AAD48251.1; -; mRNA.
DR EMBL; AF089998; AAD48252.1; -; mRNA.
DR EMBL; AF089999; AAD48253.1; -; mRNA.
DR EMBL; AF090000; AAD48254.1; -; mRNA.
DR EMBL; AF090001; AAD48255.1; -; mRNA.
DR EMBL; AF090002; AAD48256.1; -; mRNA.
DR EMBL; AF090003; AAD48257.1; -; mRNA.
DR EMBL; AF090004; AAD48258.1; -; mRNA.
DR EMBL; AF090005; AAD48259.1; -; mRNA.
DR EMBL; AF089996; AAD48250.1; -; mRNA.
DR AlphaFoldDB; Q9TVX4; -.
DR SMR; Q9TVX4; -.
DR ConoServer; 979; ABVIG mutant 1 precursor.
DR ConoServer; 972; ABVIG precursor.
DR ConoServer; 973; ABVIG precursor.
DR ConoServer; 980; ABVIG precursor.
DR ConoServer; 981; ABVIG precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Knottin; Secreted;
KW Signal; Toxin.
FT SIGNAL <1..17
FT /evidence="ECO:0000255"
FT PROPEP 18..40
FT /evidence="ECO:0000250"
FT /id="PRO_0000392122"
FT PEPTIDE 43..71
FT /note="Conotoxin AbVIG"
FT /id="PRO_0000392123"
FT DISULFID 43..57
FT /evidence="ECO:0000250"
FT DISULFID 50..61
FT /evidence="ECO:0000250"
FT DISULFID 56..68
FT /evidence="ECO:0000250"
FT CONFLICT 13
FT /note="Q -> L (in Ref. 1 and 2; AAD48258)"
FT /evidence="ECO:0000305"
FT CONFLICT 14
FT /note="L -> H (in Ref. 1 and 2; AAD48250)"
FT /evidence="ECO:0000305"
FT CONFLICT 15
FT /note="T -> A (in Ref. 1 and 2; AAD48259)"
FT /evidence="ECO:0000305"
FT CONFLICT 18
FT /note="E -> V (in Ref. 1 and 2; AAD48258)"
FT /evidence="ECO:0000305"
FT CONFLICT 36
FT /note="N -> T (in Ref. 1 and 2; AAD48259)"
FT /evidence="ECO:0000305"
FT CONFLICT 41
FT /note="K -> N (in Ref. 1 and 2; AAD48259)"
FT /evidence="ECO:0000305"
FT CONFLICT 53..54
FT /note="AY -> DN (in Ref. 1 and 2; AAD48257)"
FT /evidence="ECO:0000305"
FT NON_TER 1
SQ SEQUENCE 71 AA; 7645 MW; 61074DEC20E740A1 CRC64;
VLIIAVLFLT ACQLTTAETS SRGKQKHRAL RSTDKNSRMT KRCTAPGGAC YAAYTCCSNA
CNLNTKKCVL S
