ID   O16H_CONCE              Reviewed;          77 AA.
AC   Q3YEE2;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Conotoxin CaHr91;
DE   Flags: Precursor;
OS   Conus capitaneus (Captain cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Rhizoconus.
OX   NCBI_TaxID=89439;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RA   Luo S., Zhangsun D., Zhang B., Lin Q.;
RT   "Novel O-superfamily conotoxins, and their coding polynucleotides and
RT   use.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; DQ141171; AAZ83770.1; -; mRNA.
DR   AlphaFoldDB; Q3YEE2; -.
DR   ConoServer; 1125; CaHr91 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..43
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000414931"
FT   PEPTIDE         44..77
FT                   /note="Conotoxin CaHr91"
FT                   /id="PRO_0000414932"
FT   DISULFID        45..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        59..74
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   77 AA;  8145 MW;  8779A5385784F711 CRC64;
     MKLTCALIIT VLFLSITADD SRGKQGYRAL KSIAGMLNSK TVRECREQSQ GCTNTSPPCC
     SGLRCSGQSQ GGVCISN