ID   O16N_CONAB              Reviewed;          67 AA.
AC   Q9TVQ6; Q9UA74; Q9UA75;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Conotoxin AbVIN;
DE   Flags: Precursor; Fragment;
OS   Conus abbreviatus (Abbreviated cone) (Miliariconus abbreviatus).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Virroconus.
OX   NCBI_TaxID=100123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=10359796; DOI=10.1073/pnas.96.12.6820;
RA   Duda T.F. Jr., Palumbi S.R.;
RT   "Molecular genetics of ecological diversification: duplication and rapid
RT   evolution of toxin genes of the venomous gastropod Conus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:6820-6823(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=15306367; DOI=10.1098/rspb.2004.2708;
RA   Duda T.F. Jr., Palumbi S.R.;
RT   "Gene expression and feeding ecology: evolution of piscivory in the
RT   venomous gastropod genus Conus.";
RL   Proc. R. Soc. B 271:1165-1174(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; AF090055; AAD48308.1; -; mRNA.
DR   EMBL; AF090056; AAD48309.1; -; mRNA.
DR   EMBL; AF090057; AAD48310.1; -; mRNA.
DR   EMBL; AF090058; AAD48311.1; -; mRNA.
DR   EMBL; AF090059; AAD48312.1; -; mRNA.
DR   EMBL; AF090060; AAD48313.1; -; mRNA.
DR   EMBL; AF090061; AAD48314.1; -; mRNA.
DR   EMBL; AF090062; AAD48315.1; -; mRNA.
DR   EMBL; AF090063; AAD48316.1; -; mRNA.
DR   EMBL; AF090070; AAD48323.1; -; mRNA.
DR   AlphaFoldDB; Q9TVQ6; -.
DR   SMR; Q9TVQ6; -.
DR   ConoServer; 1037; ABVIN mutant 1 precursor.
DR   ConoServer; 1045; ABVIN mutant 2 precursor.
DR   ConoServer; 1030; ABVIN precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Knottin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          <1..17
FT                   /evidence="ECO:0000255"
FT   PROPEP          18..40
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000392136"
FT   PEPTIDE         43..67
FT                   /note="Conotoxin AbVIN"
FT                   /id="PRO_0000392137"
FT   DISULFID        43..57
FT                   /evidence="ECO:0000250"
FT   DISULFID        50..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..66
FT                   /evidence="ECO:0000250"
FT   CONFLICT        39
FT                   /note="L -> I (in Ref. 1 and 2; AAD48323)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        50
FT                   /note="C -> S (in Ref. 1 and 2; AAD48323)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        67
FT                   /note="F -> C (in Ref. 1 and 2; AAD48315)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   67 AA;  7471 MW;  A3B39852DF4E2251 CRC64;
     VIIIAVLFLT ACQLIATASY ARSERKHPDL RLSSRNSKLS KRCLGSREQC VRDTSCCSMS
     CTNNICF