ARR3_ARATH
ID ARR3_ARATH Reviewed; 231 AA.
AC Q9ZWS9;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 141.
DE RecName: Full=Two-component response regulator ARR3;
GN Name=ARR3; OrderedLocusNames=At1g59940; ORFNames=F23H11.25;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=9482949; DOI=10.1073/pnas.95.5.2691;
RA Imamura A., Hanaki N., Umeda H., Nakamura A., Suzuki T., Ueguchi C.,
RA Mizuno T.;
RT "Response regulators implicated in His-to-Asp phosphotransfer signaling in
RT Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:2691-2696(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP INDUCTION.
RX PubMed=9662428; DOI=10.1016/s0014-5793(98)00611-5;
RA Taniguchi M., Kiba T., Sakakibara H., Ueguchi C., Mizuno T., Sugiyama T.;
RT "Expression of Arabidopsis response regulator homologs is induced by
RT cytokinins and nitrate.";
RL FEBS Lett. 429:259-262(1998).
RN [5]
RP FUNCTION.
RX PubMed=14973166; DOI=10.1105/tpc.018978;
RA To J.P.C., Haberer G., Ferreira F.J., Deruere J., Mason M.G.,
RA Schaller G.E., Alonso J.M., Ecker J.R., Kieber J.J.;
RT "Type-A Arabidopsis response regulators are partially redundant negative
RT regulators of cytokinin signaling.";
RL Plant Cell 16:658-671(2004).
CC -!- FUNCTION: Functions as response regulator involved in His-to-Asp
CC phosphorelay signal transduction system. Phosphorylation of the Asp
CC residue in the receiver domain activates the ability of the protein to
CC promote the transcription of target genes. Type-A response regulators
CC seem to act as negative regulators of the cytokinin signaling.
CC {ECO:0000269|PubMed:14973166, ECO:0000269|PubMed:9482949}.
CC -!- INTERACTION:
CC Q9ZWS9; A0A384LLE4: At1g76870; NbExp=3; IntAct=EBI-1770344, EBI-25523272;
CC Q9ZWS9; Q9C9L2: TCP15; NbExp=3; IntAct=EBI-1770344, EBI-4426144;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in roots.
CC {ECO:0000269|PubMed:9482949}.
CC -!- INDUCTION: By cytokinin (zeatin) and nitrate.
CC {ECO:0000269|PubMed:9662428}.
CC -!- PTM: Two-component system major event consists of a His-to-Asp
CC phosphorelay between a sensor histidine kinase (HK) and a response
CC regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC additional intermediate named Histidine-containing phosphotransfer
CC protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC Asp sequential transfer of a phosphate group between first an His and
CC an Asp of the HK protein, followed by the transfer to a conserved His
CC of the HPt protein and finally the transfer to an Asp in the receiver
CC domain of the RR protein.
CC -!- SIMILARITY: Belongs to the ARR family. Type-A subfamily. {ECO:0000305}.
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DR EMBL; AB008486; BAA34725.1; -; mRNA.
DR EMBL; AC007258; AAD39333.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33642.1; -; Genomic_DNA.
DR PIR; T50853; T50853.
DR RefSeq; NP_176202.1; NM_104686.3.
DR AlphaFoldDB; Q9ZWS9; -.
DR SMR; Q9ZWS9; -.
DR BioGRID; 27513; 16.
DR IntAct; Q9ZWS9; 16.
DR STRING; 3702.AT1G59940.1; -.
DR PaxDb; Q9ZWS9; -.
DR ProteomicsDB; 246900; -.
DR EnsemblPlants; AT1G59940.1; AT1G59940.1; AT1G59940.
DR GeneID; 842288; -.
DR Gramene; AT1G59940.1; AT1G59940.1; AT1G59940.
DR KEGG; ath:AT1G59940; -.
DR Araport; AT1G59940; -.
DR TAIR; locus:2025911; AT1G59940.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_000445_69_5_1; -.
DR InParanoid; Q9ZWS9; -.
DR PhylomeDB; Q9ZWS9; -.
DR PRO; PR:Q9ZWS9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9ZWS9; baseline and differential.
DR Genevisible; Q9ZWS9; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IDA:TAIR.
DR GO; GO:0007623; P:circadian rhythm; IMP:TAIR.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; TAS:TAIR.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IDA:TAIR.
DR GO; GO:0010161; P:red light signaling pathway; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0009735; P:response to cytokinin; IEP:TAIR.
DR GO; GO:0010114; P:response to red light; IMP:TAIR.
DR InterPro; IPR045279; ARR-like.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43874; PTHR43874; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Cytokinin signaling pathway; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..231
FT /note="Two-component response regulator ARR3"
FT /id="PRO_0000081424"
FT DOMAIN 34..161
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT REGION 170..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 94
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 231 AA; 25250 MW; CD4950AE87FAFC91 CRC64;
MAKDGGVSCL RRSEMIGIGI GELESPPLDS DQVHVLAVDD SLVDRIVIER LLRITSCKVT
AVDSGWRALE FLGLDDDKAA VEFDRLKVDL IITDYCMPGM TGYELLKKIK ESTSFKEVPV
VIMSSENVMT RIDRCLEEGA EDFLLKPVKL ADVKRLRSYL TRDVKVAAEG NKRKLTTPPP
PPPLSATSSM ESSDSTVESP LSMVDDEDSL TMSPESATSL VDSPMRSPGL A
