ID   O17B_CONMA              Reviewed;          25 AA.
AC   P05485;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Omega-conotoxin MVIIB;
DE   AltName: Full=SNX-159;
OS   Conus magus (Magical cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX   NCBI_TaxID=6492;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT CYS-25, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=2441741; DOI=10.1021/bi00382a004;
RA   Olivera B.M., Cruz L.J., de Santos V., Lecheminant G.W., Griffin D.,
RA   Zeikus R.D., McIntosh J.M., Galyean R., Varga J., Gray W.R., Rivier J.E.;
RT   "Neuronal calcium channel antagonists. Discrimination between calcium
RT   channel subtypes using omega-conotoxin from Conus magus venom.";
RL   Biochemistry 26:2086-2090(1987).
CC   -!- FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and
CC       block voltage-gated calcium channels (Cav).
CC       {ECO:0000269|PubMed:2441741}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2441741}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:2441741}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   PIR; JH0701; JH0701.
DR   AlphaFoldDB; P05485; -.
DR   SMR; P05485; -.
DR   ConoServer; 1638; MVIIB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012321; Conotoxin_omega-typ_CS.
DR   PROSITE; PS60004; OMEGA_CONOTOXIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Calcium channel impairing toxin; Direct protein sequencing;
KW   Disulfide bond; Ion channel impairing toxin; Knottin; Neurotoxin;
KW   Presynaptic neurotoxin; Secreted; Toxin;
KW   Voltage-gated calcium channel impairing toxin.
FT   PEPTIDE         1..25
FT                   /note="Omega-conotoxin MVIIB"
FT                   /evidence="ECO:0000269|PubMed:2441741"
FT                   /id="PRO_0000044476"
FT   MOD_RES         25
FT                   /note="Cysteine amide"
FT                   /evidence="ECO:0000269|PubMed:2441741"
FT   DISULFID        1..16
FT                   /evidence="ECO:0000250|UniProtKB:P05484"
FT   DISULFID        8..20
FT                   /evidence="ECO:0000250|UniProtKB:P05484"
FT   DISULFID        15..25
FT                   /evidence="ECO:0000250|UniProtKB:P05484"
SQ   SEQUENCE   25 AA;  2626 MW;  E4B9CE5EFAA3734D CRC64;
     CKGKGASCHR TSYDCCTGSC NRGKC