ID   O194_CONTE              Reviewed;          76 AA.
AC   Q9U647;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Omega-conotoxin-like TeAr94;
DE   AltName: Full=Omega-conotoxin TxMKLT1-02121;
DE   Flags: Precursor;
OS   Conus textile (Cloth-of-gold cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=6494;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
RA   Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.;
RT   "Mechanisms for evolving hypervariability: the case of conopeptides.";
RL   Mol. Biol. Evol. 18:120-131(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=17011667; DOI=10.1016/j.peptides.2006.08.013;
RA   Luo S., Zhangsun D., Lin Q., Xie L., Wu Y., Zhu X.;
RT   "Sequence diversity of O-superfamily conopeptides from Conus marmoreus
RT   native to Hainan.";
RL   Peptides 27:3058-3068(2006).
CC   -!- FUNCTION: Omega-conotoxins act at presynaptic membranes, they bind and
CC       block voltage-gated calcium channels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; AF193269; AAF07980.1; -; mRNA.
DR   EMBL; DQ141166; AAZ83765.1; -; mRNA.
DR   AlphaFoldDB; Q9U647; -.
DR   ConoServer; 1102; TxO2 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   InterPro; IPR012321; Conotoxin_omega-typ_CS.
DR   Pfam; PF02950; Conotoxin; 1.
DR   PROSITE; PS60004; OMEGA_CONOTOXIN; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Knottin; Neurotoxin;
KW   Presynaptic neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..50
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000315476"
FT   PEPTIDE         53..76
FT                   /note="Omega-conotoxin-like TeAr94"
FT                   /id="PRO_0000315477"
FT   DISULFID        53..67
FT                   /evidence="ECO:0000250|UniProtKB:Q26443"
FT   DISULFID        60..71
FT                   /evidence="ECO:0000250|UniProtKB:Q26443"
FT   DISULFID        66..75
FT                   /evidence="ECO:0000250|UniProtKB:Q26443"
SQ   SEQUENCE   76 AA;  8508 MW;  85724AE8E0056E0C CRC64;
     MKLTCMMIVA VLFLTAWTFV TAVPHSSNAL ENLYLKAHHE MNNPEDSELN KRCYDSGTSC
     NTGNQCCSGW CIFVCL