ID   O1_VAR67                Reviewed;         666 AA.
AC   P34010;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   02-JUN-2021, entry version 58.
DE   RecName: Full=Protein O1;
GN   ORFNames=O1L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8109158; DOI=10.1016/0168-1702(93)90093-3;
RA   Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V.,
RA   Sandakhchiev L.S.;
RT   "Analysis of the nucleotide sequence of a 43 kbp segment of the genome of
RT   variola virus India-1967 strain.";
RL   Virus Res. 30:239-258(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae O1 family. {ECO:0000305}.
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DR   EMBL; X69198; CAA48994.1; -; Genomic_DNA.
DR   PIR; F36842; F36842.
DR   RefSeq; NP_042097.1; NC_001611.1.
DR   PRIDE; P34010; -.
DR   GeneID; 1486483; -.
DR   KEGG; vg:1486483; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR021155; Poxvirus_E2/O1.
DR   InterPro; IPR006732; Poxvirus_O1.
DR   Pfam; PF04497; Pox_E2-like; 2.
DR   PIRSF; PIRSF015980; VAC_O1L; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..666
FT                   /note="Protein O1"
FT                   /id="PRO_0000099640"
FT   TRANSMEM        574..596
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   666 AA;  77305 MW;  F9E9192C93A6BAAF CRC64;
     MFMYPEFARK ALSKLISKKL NIEKVSSKHQ LVLLDYGLHG LLPKSLYLEA INSDILNVRF
     FPPEIINVTD IVKALQNSCR VDEYLKAVSL YHKNSLMVSG PNVVKLMIEY NLLTHSDLEW
     LINENVIKAT YLLKINAYMI NFKIDLTVDE IIDLVKDIPV GATLHLYNIL NNLDLNIILR
     ISDEYNIPPV HDILSKLTDE EMCIKLVTKY PMENVINFIN QDVRYSPTFI KTIKDFVNAH
     LPTMYDGLND YLHSVIVDKD LIEEYKIKSV AMFNLEYKTD VDTLTLDEQI FVEVNISYYD
     FRYRQFANEF RDYIMLKESR QITMQTGDKI RRFRRPMSLR STIIKKDTDS LEDILSHIDN
     ARKNSKVSIE DVDRIISSFR LNPCVVRRTM LSNIDIKTKI MVLKIAKDWK SCALTLSAIK
     GIMVTDTINT VLSKILHHHR NVFKYLTSVD NKEITVCNCS RCVSLFYREL KSIRCDLNTD
     DGLLARLYDL TRYALHGRIN QNLIGQRCWG PLTEMLFNED KKRKLNNLMV YIKISDMLVY
     GHSIEKTLIP ITESLSFKLS VDTMSVSNDQ YAKVVIFFNT IIEYIVATIY YRLAVLNNYV
     AIRHFVLKVL HTVMEACGVL FSHIKVNDKI EHELEEMVDK GIVPSYLHHL SINVISIILD
     DINGTR