O226B_CONTE
ID O226B_CONTE Reviewed; 72 AA.
AC P0CJ21;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 1.
DT 25-MAY-2022, entry version 18.
DE RecName: Full=Conotoxin Gla(2)-TxVI/B;
DE Flags: Precursor;
OS Conus textile (Cloth-of-gold cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX NCBI_TaxID=6494;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 47-71, MASS SPECTROMETRY,
RP HYDROXYLATION AT PRO-58, GAMMA-CARBOXYGLUTAMATION AT GLU-56, BROMINATION,
RP AND AMIDATION AT SER-71.
RC TISSUE=Venom, and Venom gland;
RX PubMed=16817904; DOI=10.1111/j.1742-4658.2006.05294.x;
RA Czerwiec E., Kalume D.E., Roepstorff P., Hambe B., Furie B., Furie B.C.,
RA Stenflo J.;
RT "Novel gamma-carboxyglutamic acid-containing peptides from the venom of
RT Conus textile.";
RL FEBS J. 273:2779-2788(2006).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC -!- PTM: Brominated at one of the Trp residues.
CC {ECO:0000269|PubMed:16817904}.
CC -!- MASS SPECTROMETRY: Mass=2979.70; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:16817904};
CC -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0CJ21; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 1: Evidence at protein level;
KW Amidation; Bromination; Cleavage on pair of basic residues;
KW Direct protein sequencing; Disulfide bond; Gamma-carboxyglutamic acid;
KW Hydroxylation; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..44
FT /id="PRO_0000404790"
FT PEPTIDE 47..71
FT /note="Conotoxin Gla(2)-TxVI/B"
FT /id="PRO_0000404791"
FT MOD_RES 56
FT /note="4-carboxyglutamate"
FT /evidence="ECO:0000269|PubMed:16817904"
FT MOD_RES 58
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000269|PubMed:16817904"
FT MOD_RES 71
FT /note="Serine amide"
FT /evidence="ECO:0000269|PubMed:16817904"
FT DISULFID 48..62
FT /evidence="ECO:0000250"
FT DISULFID 55..66
FT /evidence="ECO:0000250"
FT DISULFID 61..70
FT /evidence="ECO:0000250"
SQ SEQUENCE 72 AA; 8210 MW; E1846E388C9FCBFB CRC64;
MEKLIILLLV AAVLMSTQAL FQEKRTMKKI DFLSKGKADA EKQRKRNCSD DWQYCESPSD
CCSWDCDVVC SG