ID   O261_CONMR              Reviewed;          73 AA.
AC   Q3YEF4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 2.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Conotoxin MaI51;
DE   Flags: Precursor;
OS   Conus marmoreus (Marble cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Conus.
OX   NCBI_TaxID=42752;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=17011667; DOI=10.1016/j.peptides.2006.08.013;
RA   Luo S., Zhangsun D., Lin Q., Xie L., Wu Y., Zhu X.;
RT   "Sequence diversity of O-superfamily conopeptides from Conus marmoreus
RT   native to Hainan.";
RL   Peptides 27:3058-3068(2006).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
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DR   EMBL; DQ141159; AAZ83760.2; -; mRNA.
DR   AlphaFoldDB; Q3YEF4; -.
DR   SMR; Q3YEF4; -.
DR   ConoServer; 1178; MaI51 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Knottin;
KW   Neurotoxin; Pyrrolidone carboxylic acid; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..41
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000315512"
FT   PEPTIDE         46..72
FT                   /note="Conotoxin MaI51"
FT                   /id="PRO_0000315513"
FT   MOD_RES         46
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         72
FT                   /note="Isoleucine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..69
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   73 AA;  8394 MW;  6EDBCD6AE267CB76 CRC64;
     MQKLTILLLV AAVLLSTQAL NQEKRPKEMI NVLSKGKTNA ERRKRQCEDV WMPCTSNWEC
     CSLDCEMYCT QIG