O261_CONTE
ID O261_CONTE Reviewed; 79 AA.
AC Q9BHB7;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 50.
DE RecName: Full=Conotoxin TxMEKL-021;
DE AltName: Full=Conotoxin TxMEKL-022;
DE Flags: Precursor;
OS Conus textile (Cloth-of-gold cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX NCBI_TaxID=6494;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
RA Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.;
RT "Mechanisms for evolving hypervariability: the case of conopeptides.";
RL Mol. Biol. Evol. 18:120-131(2001).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF215018; AAG60446.1; -; mRNA.
DR EMBL; AF215027; AAG60455.1; -; mRNA.
DR AlphaFoldDB; Q9BHB7; -.
DR ConoServer; 705; TxMEKL-022/TxMEKL-021 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..47
FT /evidence="ECO:0000255"
FT /id="PRO_0000404786"
FT PEPTIDE 48..79
FT /note="Conotoxin TxMEKL-021"
FT /evidence="ECO:0000255"
FT /id="PRO_0000404787"
FT DISULFID 51..65
FT /evidence="ECO:0000250"
FT DISULFID 58..69
FT /evidence="ECO:0000250"
FT DISULFID 64..75
FT /evidence="ECO:0000250"
SQ SEQUENCE 79 AA; 8915 MW; 1A281EA818DE1A8C CRC64;
MEKLTILLLV AVVLMSTQAL PQGGGEKRPR ENIRFLSKRK SNAERWREGS CTSWLATCTD
ASQCCTGVCY KRAYCALWE