O264_CONBE
ID O264_CONBE Reviewed; 77 AA.
AC Q3YEF9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 29-SEP-2021, entry version 31.
DE RecName: Full=Conotoxin Bt6.6 {ECO:0000305};
DE AltName: Full=Conotoxin BeB54 {ECO:0000303|PubMed:17177885};
DE Flags: Precursor;
OS Conus betulinus (Beech cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Dendroconus.
OX NCBI_TaxID=89764;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=17177885; DOI=10.1111/j.1747-0285.2006.00443.x;
RA Zhangsun D., Luo S., Wu Y., Zhu X., Hu Y., Xie L.;
RT "Novel O-superfamily conotoxins identified by cDNA cloning from three
RT vermivorous Conus species.";
RL Chem. Biol. Drug Des. 68:256-265(2006).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
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DR EMBL; DQ141154; AAZ83755.1; -; mRNA.
DR ConoServer; 1115; BeB54 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Knottin; Neurotoxin;
KW Secreted; Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..38
FT /evidence="ECO:0000305"
FT /id="PRO_0000315480"
FT PEPTIDE 41..77
FT /note="Conotoxin Bt6.6"
FT /id="PRO_0000315481"
FT DISULFID 51..65
FT /evidence="ECO:0000250"
FT DISULFID 58..69
FT /evidence="ECO:0000250"
FT DISULFID 64..74
FT /evidence="ECO:0000250"
SQ SEQUENCE 77 AA; 8991 MW; 342D794E1C2F8BA5 CRC64;
MEKLTILLLV AAVLMSTQAL IQSDGEKRQQ AKINFLSXRK STAESWWEGE CKGWSVYCSW
DWECCSGECT RYYCELW