ID   O2651_CONLT             Reviewed;          76 AA.
AC   Q3YEF7;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Conotoxin LeD51;
DE   Flags: Precursor;
OS   Conus litteratus (Lettered cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Elisaconus.
OX   NCBI_TaxID=89445;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Luo S., Zhangsun D., Zhang B., Lin Q.;
RT   "Novel O-superfamily conotoxins, and their coding polynucleotides and
RT   use.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
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DR   EMBL; DQ141156; AAZ83757.1; -; mRNA.
DR   AlphaFoldDB; Q3YEF7; -.
DR   ConoServer; 1116; Lt6.2 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..45
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000404814"
FT   PEPTIDE         46..76
FT                   /note="Conotoxin LeD51"
FT                   /id="PRO_0000404815"
FT   DISULFID        51..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..69
FT                   /evidence="ECO:0000250"
FT   DISULFID        64..73
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   76 AA;  8493 MW;  E82FCFEBBD65B34D CRC64;
     MEKLTILLLV AAVLMSTQAL VERAGENRSK ENIKFLLKRK RAADRGMWGK CKDGLTTCLA
     PSECCSGNCE QNCKMW