ARR5_ARATH
ID ARR5_ARATH Reviewed; 184 AA.
AC Q9SB04; O80364; Q9SBH9;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Two-component response regulator ARR5;
DE AltName: Full=Response reactor 2;
GN Name=ARR5; Synonyms=ATRR2, IBC6; OrderedLocusNames=At3g48100;
GN ORFNames=T17F15.30;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=9482949; DOI=10.1073/pnas.95.5.2691;
RA Imamura A., Hanaki N., Umeda H., Nakamura A., Suzuki T., Ueguchi C.,
RA Mizuno T.;
RT "Response regulators implicated in His-to-Asp phosphotransfer signaling in
RT Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:2691-2696(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=cv. Columbia;
RX PubMed=9607306; DOI=10.1016/s0014-5793(98)00418-9;
RA Urao T., Yakubov B., Yamaguchi-Shinozaki K., Shinozaki K.;
RT "Stress-responsive expression of genes for two-component response
RT regulator-like proteins in Arabidopsis thaliana.";
RL FEBS Lett. 427:175-178(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=cv. Wassilewskija;
RX PubMed=9634588; DOI=10.2307/3870686;
RA Brandstatter I., Kieber J.J.;
RT "Two genes with similarity to bacterial response regulators are rapidly and
RT specifically induced by cytokinin in Arabidopsis.";
RL Plant Cell 10:1009-1019(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [7]
RP INDUCTION.
RX PubMed=9662428; DOI=10.1016/s0014-5793(98)00611-5;
RA Taniguchi M., Kiba T., Sakakibara H., Ueguchi C., Mizuno T., Sugiyama T.;
RT "Expression of Arabidopsis response regulator homologs is induced by
RT cytokinins and nitrate.";
RL FEBS Lett. 429:259-262(1998).
RN [8]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=11115887; DOI=10.1104/pp.124.4.1706;
RA D'Agostino I.B., Deruere J., Kieber J.J.;
RT "Characterization of the response of the Arabidopsis response regulator
RT gene family to cytokinin.";
RL Plant Physiol. 124:1706-1717(2000).
RN [9]
RP FUNCTION.
RX PubMed=14973166; DOI=10.1105/tpc.018978;
RA To J.P.C., Haberer G., Ferreira F.J., Deruere J., Mason M.G.,
RA Schaller G.E., Alonso J.M., Ecker J.R., Kieber J.J.;
RT "Type-A Arabidopsis response regulators are partially redundant negative
RT regulators of cytokinin signaling.";
RL Plant Cell 16:658-671(2004).
CC -!- FUNCTION: Functions as response regulator involved in His-to-Asp
CC phosphorelay signal transduction system. Phosphorylation of the Asp
CC residue in the receiver domain activates the ability of the protein to
CC promote the transcription of target genes. Type-A response regulators
CC seem to act as negative regulators of the cytokinin signaling.
CC {ECO:0000269|PubMed:14973166, ECO:0000269|PubMed:9482949}.
CC -!- INTERACTION:
CC Q9SB04; Q9ZNV9: AHP1; NbExp=2; IntAct=EBI-1100883, EBI-1100673;
CC Q9SB04; Q9SAZ5: AHP3; NbExp=3; IntAct=EBI-1100883, EBI-1100711;
CC Q9SB04; Q67XQ1: At1g03430; NbExp=3; IntAct=EBI-1100883, EBI-1100725;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in roots and shoot apical
CC meristems. {ECO:0000269|PubMed:11115887, ECO:0000269|PubMed:9482949,
CC ECO:0000269|PubMed:9607306, ECO:0000269|PubMed:9634588}.
CC -!- INDUCTION: By low temperature, dehydration, cytokinins (BA and zeatin),
CC nitrate and high salinity. {ECO:0000269|PubMed:11115887,
CC ECO:0000269|PubMed:9607306, ECO:0000269|PubMed:9634588,
CC ECO:0000269|PubMed:9662428}.
CC -!- PTM: Two-component system major event consists of a His-to-Asp
CC phosphorelay between a sensor histidine kinase (HK) and a response
CC regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC additional intermediate named Histidine-containing phosphotransfer
CC protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC Asp sequential transfer of a phosphate group between first an His and
CC an Asp of the HK protein, followed by the transfer to a conserved His
CC of the HPt protein and finally the transfer to an Asp in the receiver
CC domain of the RR protein.
CC -!- SIMILARITY: Belongs to the ARR family. Type-A subfamily. {ECO:0000305}.
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DR EMBL; AB008488; BAA34727.1; -; mRNA.
DR EMBL; AB010916; BAA31144.1; -; mRNA.
DR EMBL; AF057281; AAC26635.1; -; mRNA.
DR EMBL; AL049658; CAB41129.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78368.1; -; Genomic_DNA.
DR EMBL; AY072390; AAL62382.1; -; mRNA.
DR EMBL; AY114698; AAM48017.1; -; mRNA.
DR PIR; T06673; T06673.
DR PIR; T50855; T50855.
DR PIR; T50856; T50856.
DR RefSeq; NP_190393.1; NM_114679.4.
DR AlphaFoldDB; Q9SB04; -.
DR SMR; Q9SB04; -.
DR BioGRID; 9284; 28.
DR IntAct; Q9SB04; 28.
DR STRING; 3702.AT3G48100.1; -.
DR PaxDb; Q9SB04; -.
DR PRIDE; Q9SB04; -.
DR ProteomicsDB; 246901; -.
DR EnsemblPlants; AT3G48100.1; AT3G48100.1; AT3G48100.
DR GeneID; 823965; -.
DR Gramene; AT3G48100.1; AT3G48100.1; AT3G48100.
DR KEGG; ath:AT3G48100; -.
DR Araport; AT3G48100; -.
DR TAIR; locus:2097870; AT3G48100.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_000445_69_5_1; -.
DR InParanoid; Q9SB04; -.
DR OMA; RAFKNIM; -.
DR OrthoDB; 1311174at2759; -.
DR PhylomeDB; Q9SB04; -.
DR PRO; PR:Q9SB04; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SB04; baseline and differential.
DR Genevisible; Q9SB04; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IMP:TAIR.
DR GO; GO:0007623; P:circadian rhythm; IMP:TAIR.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0009735; P:response to cytokinin; IEP:TAIR.
DR GO; GO:0010114; P:response to red light; IMP:TAIR.
DR InterPro; IPR045279; ARR-like.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43874; PTHR43874; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Cytokinin signaling pathway; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..184
FT /note="Two-component response regulator ARR5"
FT /id="PRO_0000081426"
FT DOMAIN 26..154
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT MOD_RES 87
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT CONFLICT 159
FT /note="R -> G (in Ref. 3; AAC26635)"
FT /evidence="ECO:0000305"
FT CONFLICT 163
FT /note="N -> D (in Ref. 1; BAA34727)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 184 AA; 20879 MW; 5D2B7822DCC8CFA5 CRC64;
MAEVLRPEML DISNDTSSLA SPKLLHVLAV DDSMVDRKFI ERLLRVSSCK VTVVDSATRA
LQYLGLDGEN NSSVGFEDLK INLIMTDYSM PGMTGYELLK KIKESSAFRE IPVVIMSSEN
ILPRIDRCLE EGAEDFLLKP VKLADVKRLR DSLMKAEERA FKNIMHKREL EANDIYSQLK
RAKI
