O268_CONVC
ID O268_CONVC Reviewed; 74 AA.
AC G1AS74;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 25-MAY-2022, entry version 22.
DE RecName: Full=Conotoxin Vc6.8;
DE Flags: Precursor;
OS Conus victoriae (Queen Victoria cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX NCBI_TaxID=319920;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo, and Venom duct;
RX PubMed=21504902; DOI=10.1074/jbc.m110.217703;
RA Safavi-Hemami H., Siero W.A., Kuang Z., Williamson N.A., Karas J.A.,
RA Page L.R., Macmillan D., Callaghan B., Kompella S.N., Adams D.J.,
RA Norton R.S., Purcell A.W.;
RT "Embryonic toxin expression in the cone snail Conus victoriae: primed to
RT kill or divergent function?";
RL J. Biol. Chem. 286:22546-22557(2011).
CC -!- FUNCTION: Inhibits voltage-gated ion channels. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DEVELOPMENTAL STAGE: Only expressed in adults.
CC {ECO:0000269|PubMed:21504902}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
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DR EMBL; JF433901; AEA35357.1; -; mRNA.
DR AlphaFoldDB; G1AS74; -.
DR ConoServer; 4269; Vc6.8 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond;
KW Ion channel impairing toxin; Secreted; Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..34
FT /evidence="ECO:0000250"
FT /id="PRO_0000425165"
FT PEPTIDE 38..74
FT /note="Conotoxin Vc6.8"
FT /id="PRO_0000425166"
FT DISULFID 49..62
FT /evidence="ECO:0000250"
FT DISULFID 55..66
FT /evidence="ECO:0000250"
FT DISULFID 61..70
FT /evidence="ECO:0000250"
SQ SEQUENCE 74 AA; 8275 MW; A29DA5CA2ABB76C1 CRC64;
MEKLTILLLV AAVLMSTQAL MQEQRQKAKI NLFSKRRLSA ESWWEENGCS LWGPCTVNAE
CCSGDCDETC IFGS