ID   O269_CONIM              Reviewed;          76 AA.
AC   A0A125S9F3;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2016, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Conotoxin Im6.9 {ECO:0000305};
DE   AltName: Full=Conopeptide im019 {ECO:0000303|PubMed:30893765, ECO:0000312|EMBL:AME17677.1};
DE   Flags: Precursor;
OS   Conus imperialis (Imperial cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX   NCBI_TaxID=35631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=30893765; DOI=10.3390/md17030177;
RA   Jin A.H., Dutertre S., Dutt M., Lavergne V., Jones A., Lewis R.J.,
RA   Alewood P.F.;
RT   "Transcriptomic-proteomic correlation in the predation-evoked venom of the
RT   cone snail, Conus imperialis.";
RL   Mar. Drugs 17:0-0(2019).
CC   -!- FUNCTION: Probable neurotoxin. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30893765}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:30893765}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KT377413; AME17677.1; -; mRNA.
DR   AlphaFoldDB; A0A125S9F3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..45
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000451005"
FT   CHAIN           46..76
FT                   /note="Conotoxin Im6.9"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5007179721"
FT   DISULFID        51..65
FT                   /evidence="ECO:0000305"
FT   DISULFID        58..69
FT                   /evidence="ECO:0000305"
FT   DISULFID        64..73
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   76 AA;  8744 MW;  69829F6BB7EB8B04 CRC64;
     MEKLTILLLV TAVLMSTQAL MQSGIEKRQR AKIKFFSKRK TTAERWWEGE CYDWLRQCSS
     PAQCCSGNCG AHCKAW