ARR6_ARATH
ID ARR6_ARATH Reviewed; 186 AA.
AC Q9ZWS6; Q9ZWS8;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Two-component response regulator ARR6;
GN Name=ARR6; OrderedLocusNames=At5g62920; ORFNames=MQB2.220, MQB2.24;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=9482949; DOI=10.1073/pnas.95.5.2691;
RA Imamura A., Hanaki N., Umeda H., Nakamura A., Suzuki T., Ueguchi C.,
RA Mizuno T.;
RT "Response regulators implicated in His-to-Asp phosphotransfer signaling in
RT Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:2691-2696(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT features of the regions of 1,456,315 bp covered by nineteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:41-54(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP INDUCTION.
RX PubMed=9662428; DOI=10.1016/s0014-5793(98)00611-5;
RA Taniguchi M., Kiba T., Sakakibara H., Ueguchi C., Mizuno T., Sugiyama T.;
RT "Expression of Arabidopsis response regulator homologs is induced by
RT cytokinins and nitrate.";
RL FEBS Lett. 429:259-262(1998).
RN [6]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=11115887; DOI=10.1104/pp.124.4.1706;
RA D'Agostino I.B., Deruere J., Kieber J.J.;
RT "Characterization of the response of the Arabidopsis response regulator
RT gene family to cytokinin.";
RL Plant Physiol. 124:1706-1717(2000).
RN [7]
RP SUBCELLULAR LOCATION.
RX PubMed=11574878; DOI=10.1038/35096500;
RA Hwang I., Sheen J.;
RT "Two-component circuitry in Arabidopsis cytokinin signal transduction.";
RL Nature 413:383-389(2001).
RN [8]
RP FUNCTION.
RX PubMed=14973166; DOI=10.1105/tpc.018978;
RA To J.P.C., Haberer G., Ferreira F.J., Deruere J., Mason M.G.,
RA Schaller G.E., Alonso J.M., Ecker J.R., Kieber J.J.;
RT "Type-A Arabidopsis response regulators are partially redundant negative
RT regulators of cytokinin signaling.";
RL Plant Cell 16:658-671(2004).
CC -!- FUNCTION: Functions as response regulator involved in His-to-Asp
CC phosphorelay signal transduction system. Phosphorylation of the Asp
CC residue in the receiver domain activates the ability of the protein to
CC promote the transcription of target genes. Type-A response regulators
CC seem to act as negative regulators of the cytokinin signaling.
CC {ECO:0000269|PubMed:14973166, ECO:0000269|PubMed:9482949}.
CC -!- INTERACTION:
CC Q9ZWS6; Q67XQ1: At1g03430; NbExp=2; IntAct=EBI-1100901, EBI-1100725;
CC Q9ZWS6; Q9C9L2: TCP15; NbExp=3; IntAct=EBI-1100901, EBI-4426144;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11574878}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in roots.
CC {ECO:0000269|PubMed:11115887, ECO:0000269|PubMed:9482949}.
CC -!- INDUCTION: By cytokinins (BA and zeatin) and nitrate.
CC {ECO:0000269|PubMed:11115887, ECO:0000269|PubMed:9662428}.
CC -!- PTM: Two-component system major event consists of a His-to-Asp
CC phosphorelay between a sensor histidine kinase (HK) and a response
CC regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC additional intermediate named Histidine-containing phosphotransfer
CC protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC Asp sequential transfer of a phosphate group between first an His and
CC an Asp of the HK protein, followed by the transfer to a conserved His
CC of the HPt protein and finally the transfer to an Asp in the receiver
CC domain of the RR protein.
CC -!- SIMILARITY: Belongs to the ARR family. Type-A subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA34730.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB008489; BAA34728.1; -; mRNA.
DR EMBL; AB008491; BAA34730.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB009053; BAB10861.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97674.1; -; Genomic_DNA.
DR EMBL; BT004799; AAO44065.1; -; mRNA.
DR PIR; T50857; T50857.
DR PIR; T50860; T50860.
DR RefSeq; NP_201097.1; NM_125686.3.
DR AlphaFoldDB; Q9ZWS6; -.
DR SMR; Q9ZWS6; -.
DR BioGRID; 21655; 16.
DR IntAct; Q9ZWS6; 17.
DR STRING; 3702.AT5G62920.1; -.
DR PaxDb; Q9ZWS6; -.
DR PRIDE; Q9ZWS6; -.
DR ProteomicsDB; 246673; -.
DR EnsemblPlants; AT5G62920.1; AT5G62920.1; AT5G62920.
DR GeneID; 836412; -.
DR Gramene; AT5G62920.1; AT5G62920.1; AT5G62920.
DR KEGG; ath:AT5G62920; -.
DR Araport; AT5G62920; -.
DR TAIR; locus:2170723; AT5G62920.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_000445_69_5_1; -.
DR InParanoid; Q9ZWS6; -.
DR OMA; ETENAYP; -.
DR OrthoDB; 1311174at2759; -.
DR PhylomeDB; Q9ZWS6; -.
DR PRO; PR:Q9ZWS6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9ZWS6; baseline and differential.
DR Genevisible; Q9ZWS6; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0000156; F:phosphorelay response regulator activity; ISS:TAIR.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0009735; P:response to cytokinin; IEP:TAIR.
DR InterPro; IPR045279; ARR-like.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43874; PTHR43874; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Cytokinin signaling pathway; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..186
FT /note="Two-component response regulator ARR6"
FT /id="PRO_0000081427"
FT DOMAIN 26..153
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT MOD_RES 86
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 186 AA; 21239 MW; D3092FDF043A8987 CRC64;
MAEVMLPRKM EILNHSSKFG SPDPLHVLAV DDSHVDRKFI ERLLRVSSCK VTVVDSATRA
LQYLGLDVEE KSVGFEDLKV NLIMTDYSMP GMTGYELLKK IKESSAFREV PVVIMSSENI
LPRIDRCLEE GAEDFLLKPV KLSDVKRLRD SLMKVEDLSF TKSIQKRELE TENVYPVHSQ
LKRAKI
