O26B_CONST
ID O26B_CONST Reviewed; 77 AA.
AC P0C834;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 25-MAY-2022, entry version 24.
DE RecName: Full=Conotoxin S6.11;
DE Flags: Precursor;
OS Conus striatus (Striated cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Pionoconus.
OX NCBI_TaxID=6493;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom duct;
RX PubMed=16183187; DOI=10.1016/j.biochi.2005.08.001;
RA Pi C., Liu Y., Peng C., Jiang X., Liu J., Xu B., Yu X., Yu Y., Jiang X.,
RA Wang L., Dong M., Chen S., Xu A.-L.;
RT "Analysis of expressed sequence tags from the venom ducts of Conus
RT striatus: focusing on the expression profile of conotoxins.";
RL Biochimie 88:131-140(2006).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
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DR AlphaFoldDB; P0C834; -.
DR SMR; P0C834; -.
DR ConoServer; 3539; S6.11 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..50
FT /evidence="ECO:0000250"
FT /id="PRO_0000345110"
FT PEPTIDE 51..77
FT /note="Conotoxin S6.11"
FT /id="PRO_0000345111"
FT DISULFID 51..65
FT /evidence="ECO:0000250"
FT DISULFID 58..69
FT /evidence="ECO:0000250"
FT DISULFID 64..74
FT /evidence="ECO:0000250"
SQ SEQUENCE 77 AA; 8754 MW; 4332CF90F7A454F9 CRC64;
MEKLTILLLV AAVLMSTQAL IQGGLDERQK AKSNFFSKRK SNAESWWEGE CRTWNAPCSF
TSQCCFGKCA HHRCIAW