O26B_CONVC
ID O26B_CONVC Reviewed; 74 AA.
AC G1AS77;
DT 22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 25-MAY-2022, entry version 22.
DE RecName: Full=Conotoxin Vc6.11;
DE Flags: Precursor;
OS Conus victoriae (Queen Victoria cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX NCBI_TaxID=319920;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo, and Venom duct;
RX PubMed=21504902; DOI=10.1074/jbc.m110.217703;
RA Safavi-Hemami H., Siero W.A., Kuang Z., Williamson N.A., Karas J.A.,
RA Page L.R., Macmillan D., Callaghan B., Kompella S.N., Adams D.J.,
RA Norton R.S., Purcell A.W.;
RT "Embryonic toxin expression in the cone snail Conus victoriae: primed to
RT kill or divergent function?";
RL J. Biol. Chem. 286:22546-22557(2011).
CC -!- FUNCTION: Inhibits voltage-gated ion channels. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC -!- DEVELOPMENTAL STAGE: Only expressed in adults.
CC {ECO:0000269|PubMed:21504902}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
CC -!- CAUTION: Contains only 5 Cys residues instead of the 6 residues that
CC are usually found in the O2 superfamily. {ECO:0000305}.
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DR EMBL; JF433904; AEA35360.1; -; mRNA.
DR AlphaFoldDB; G1AS77; -.
DR ConoServer; 4272; Vc6.11 precursor.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR InterPro; IPR004214; Conotoxin.
DR Pfam; PF02950; Conotoxin; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Ion channel impairing toxin; Secreted; Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..41
FT /evidence="ECO:0000250"
FT /id="PRO_0000425171"
FT PEPTIDE 43..74
FT /note="Conotoxin Vc6.11"
FT /id="PRO_0000425172"
FT DISULFID 55..66
FT /evidence="ECO:0000250"
FT DISULFID 61..71
FT /evidence="ECO:0000250"
SQ SEQUENCE 74 AA; 8579 MW; D6447268FE7CFA0B CRC64;
MEKLTILLLV AAVLMSTQAL IQEQRQKAKI NLFSKRKPSA ERWWGENDRR VFGSCTADEE
CCFNNCVQAY CFFV