ID   O26C_CONVC              Reviewed;          71 AA.
AC   G1AS78;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Conotoxin Vc6.12;
DE   Flags: Precursor;
OS   Conus victoriae (Queen Victoria cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=319920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryo, and Venom duct;
RX   PubMed=21504902; DOI=10.1074/jbc.m110.217703;
RA   Safavi-Hemami H., Siero W.A., Kuang Z., Williamson N.A., Karas J.A.,
RA   Page L.R., Macmillan D., Callaghan B., Kompella S.N., Adams D.J.,
RA   Norton R.S., Purcell A.W.;
RT   "Embryonic toxin expression in the cone snail Conus victoriae: primed to
RT   kill or divergent function?";
RL   J. Biol. Chem. 286:22546-22557(2011).
CC   -!- FUNCTION: Inhibits voltage-gated ion channels. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DEVELOPMENTAL STAGE: Only expressed in adults.
CC       {ECO:0000269|PubMed:21504902}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
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DR   EMBL; JF433905; AEA35361.1; -; mRNA.
DR   AlphaFoldDB; G1AS78; -.
DR   ConoServer; 4273; Vc6.12 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..43
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000425173"
FT   PEPTIDE         47..71
FT                   /note="Conotoxin Vc6.12"
FT                   /id="PRO_0000425174"
FT   DISULFID        48..62
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        61..70
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   71 AA;  8248 MW;  A01FA5D5F264748A CRC64;
     MQKLIILLLV AAVLMSTQAL FQEKRPMKKI NFLSKGKTDA EKQRKRSCSD DWQYCEYPHD
     CCSWSCDVVC S