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ARR7_ARATH
ID   ARR7_ARATH              Reviewed;         206 AA.
AC   Q9ZWS7;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Two-component response regulator ARR7;
GN   Name=ARR7; OrderedLocusNames=At1g19050; ORFNames=F14D16.20;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   STRAIN=cv. Columbia;
RX   PubMed=9482949; DOI=10.1073/pnas.95.5.2691;
RA   Imamura A., Hanaki N., Umeda H., Nakamura A., Suzuki T., Ueguchi C.,
RA   Mizuno T.;
RT   "Response regulators implicated in His-to-Asp phosphotransfer signaling in
RT   Arabidopsis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:2691-2696(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   INDUCTION.
RX   PubMed=9662428; DOI=10.1016/s0014-5793(98)00611-5;
RA   Taniguchi M., Kiba T., Sakakibara H., Ueguchi C., Mizuno T., Sugiyama T.;
RT   "Expression of Arabidopsis response regulator homologs is induced by
RT   cytokinins and nitrate.";
RL   FEBS Lett. 429:259-262(1998).
RN   [5]
RP   TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=11115887; DOI=10.1104/pp.124.4.1706;
RA   D'Agostino I.B., Deruere J., Kieber J.J.;
RT   "Characterization of the response of the Arabidopsis response regulator
RT   gene family to cytokinin.";
RL   Plant Physiol. 124:1706-1717(2000).
RN   [6]
RP   FUNCTION.
RX   PubMed=14973166; DOI=10.1105/tpc.018978;
RA   To J.P.C., Haberer G., Ferreira F.J., Deruere J., Mason M.G.,
RA   Schaller G.E., Alonso J.M., Ecker J.R., Kieber J.J.;
RT   "Type-A Arabidopsis response regulators are partially redundant negative
RT   regulators of cytokinin signaling.";
RL   Plant Cell 16:658-671(2004).
CC   -!- FUNCTION: Functions as response regulator involved in His-to-Asp
CC       phosphorelay signal transduction system. Phosphorylation of the Asp
CC       residue in the receiver domain activates the ability of the protein to
CC       promote the transcription of target genes. Type-A response regulators
CC       seem to act as negative regulators of the cytokinin signaling.
CC       {ECO:0000269|PubMed:14973166, ECO:0000269|PubMed:9482949}.
CC   -!- INTERACTION:
CC       Q9ZWS7; Q9ZNV8: AHP2; NbExp=6; IntAct=EBI-1100917, EBI-1100687;
CC       Q9ZWS7; Q9SAZ5: AHP3; NbExp=4; IntAct=EBI-1100917, EBI-1100711;
CC       Q9ZWS7; Q67XQ1: At1g03430; NbExp=3; IntAct=EBI-1100917, EBI-1100725;
CC       Q9ZWS7; Q8L831: NUDT3; NbExp=2; IntAct=EBI-1100917, EBI-1807753;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in roots and young flowers.
CC       {ECO:0000269|PubMed:11115887, ECO:0000269|PubMed:9482949}.
CC   -!- INDUCTION: By cytokinins (BA and zeatin) and nitrate.
CC       {ECO:0000269|PubMed:11115887, ECO:0000269|PubMed:9662428}.
CC   -!- PTM: Two-component system major event consists of a His-to-Asp
CC       phosphorelay between a sensor histidine kinase (HK) and a response
CC       regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC       additional intermediate named Histidine-containing phosphotransfer
CC       protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC       Asp sequential transfer of a phosphate group between first an His and
CC       an Asp of the HK protein, followed by the transfer to a conserved His
CC       of the HPt protein and finally the transfer to an Asp in the receiver
CC       domain of the RR protein.
CC   -!- SIMILARITY: Belongs to the ARR family. Type-A subfamily. {ECO:0000305}.
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DR   EMBL; AB008490; BAA34729.1; -; mRNA.
DR   EMBL; AC068602; AAF79300.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE29795.1; -; Genomic_DNA.
DR   PIR; T50854; T50854.
DR   RefSeq; NP_173339.1; NM_101763.3.
DR   AlphaFoldDB; Q9ZWS7; -.
DR   SMR; Q9ZWS7; -.
DR   BioGRID; 23726; 19.
DR   IntAct; Q9ZWS7; 18.
DR   STRING; 3702.AT1G19050.1; -.
DR   PaxDb; Q9ZWS7; -.
DR   PRIDE; Q9ZWS7; -.
DR   EnsemblPlants; AT1G19050.1; AT1G19050.1; AT1G19050.
DR   GeneID; 838487; -.
DR   Gramene; AT1G19050.1; AT1G19050.1; AT1G19050.
DR   KEGG; ath:AT1G19050; -.
DR   Araport; AT1G19050; -.
DR   TAIR; locus:2011286; AT1G19050.
DR   eggNOG; KOG1601; Eukaryota.
DR   HOGENOM; CLU_000445_69_5_1; -.
DR   InParanoid; Q9ZWS7; -.
DR   OMA; LPRIEEC; -.
DR   OrthoDB; 1311174at2759; -.
DR   PhylomeDB; Q9ZWS7; -.
DR   PRO; PR:Q9ZWS7; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9ZWS7; baseline and differential.
DR   Genevisible; Q9ZWS7; AT.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; ISS:TAIR.
DR   GO; GO:0009736; P:cytokinin-activated signaling pathway; IMP:TAIR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR   GO; GO:0009735; P:response to cytokinin; IEP:TAIR.
DR   GO; GO:0019827; P:stem cell population maintenance; IMP:TAIR.
DR   InterPro; IPR045279; ARR-like.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   PANTHER; PTHR43874; PTHR43874; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   Cytokinin signaling pathway; Nucleus; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..206
FT                   /note="Two-component response regulator ARR7"
FT                   /id="PRO_0000081428"
FT   DOMAIN          25..152
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   REGION          165..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        165..195
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         85
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   206 AA;  22800 MW;  D13D14A540014DEB CRC64;
     MAVGEVMRME IPAGGDLTVT TPELHVLAVD DSIVDRKVIE RLLRISSCKV TTVESGTRAL
     QYLGLDGGKG ASNLKDLKVN LIVTDYSMPG LSGYDLLKKI KESSAFREVP VVIMSSENIL
     PRIQECLKEG AEEFLLKPVK LADVKRIKQL IMRNEAEECK ILSHSNKRKL QEDSDTSSSS
     HDDTSIKDSS CSKRMKSESE NLFSLL
 
 
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