ID   O26X_CONTS              Reviewed;          66 AA.
AC   Q9BPC0;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Conotoxin TsMEKL-03;
DE   Flags: Precursor; Fragment;
OS   Conus tessulatus (Tessellate cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Tesselliconus.
OX   NCBI_TaxID=101317;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
RA   Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z., Fainzilber M.;
RT   "Mechanisms for evolving hypervariability: the case of conopeptides.";
RL   Mol. Biol. Evol. 18:120-131(2001).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O2 superfamily. {ECO:0000305}.
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DR   EMBL; AF215014; AAG60442.1; -; mRNA.
DR   AlphaFoldDB; Q9BPC0; -.
DR   ConoServer; 701; TsMEKL-03 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          <1..9
FT                   /evidence="ECO:0000255"
FT   PROPEP          10..38
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000404832"
FT   PEPTIDE         39..66
FT                   /note="Conotoxin TsMEKL-03"
FT                   /id="PRO_0000404833"
FT   DISULFID        40..54
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..63
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   66 AA;  7594 MW;  7EB2412DBD16E412 CRC64;
     VILLMSTQAL IQSGVEKRSN KIKALSKRKT TAESWWEGEC YGWWTSCSSP EQCCSLNCEN
     IYCRAW