ARR8_ARATH
ID ARR8_ARATH Reviewed; 225 AA.
AC O80365;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Two-component response regulator ARR8;
DE AltName: Full=Response reactor 3;
GN Name=ARR8; Synonyms=ATRR3; OrderedLocusNames=At2g41310; ORFNames=F13H10.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=9607306; DOI=10.1016/s0014-5793(98)00418-9;
RA Urao T., Yakubov B., Yamaguchi-Shinozaki K., Shinozaki K.;
RT "Stress-responsive expression of genes for two-component response
RT regulator-like proteins in Arabidopsis thaliana.";
RL FEBS Lett. 427:175-178(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP FUNCTION.
RX PubMed=14973166; DOI=10.1105/tpc.018978;
RA To J.P.C., Haberer G., Ferreira F.J., Deruere J., Mason M.G.,
RA Schaller G.E., Alonso J.M., Ecker J.R., Kieber J.J.;
RT "Type-A Arabidopsis response regulators are partially redundant negative
RT regulators of cytokinin signaling.";
RL Plant Cell 16:658-671(2004).
CC -!- FUNCTION: Functions as response regulator involved in His-to-Asp
CC phosphorelay signal transduction system. Phosphorylation of the Asp
CC residue in the receiver domain activates the ability of the protein to
CC promote the transcription of target genes. Type-A response regulators
CC seem to act as negative regulators of the cytokinin signaling.
CC {ECO:0000269|PubMed:14973166}.
CC -!- INTERACTION:
CC O80365; Q67XQ1: At1g03430; NbExp=3; IntAct=EBI-1100933, EBI-1100725;
CC O80365; Q9C9L2: TCP15; NbExp=3; IntAct=EBI-1100933, EBI-4426144;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in roots.
CC {ECO:0000269|PubMed:9607306}.
CC -!- PTM: Two-component system major event consists of a His-to-Asp
CC phosphorelay between a sensor histidine kinase (HK) and a response
CC regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC additional intermediate named Histidine-containing phosphotransfer
CC protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC Asp sequential transfer of a phosphate group between first an His and
CC an Asp of the HK protein, followed by the transfer to a conserved His
CC of the HPt protein and finally the transfer to an Asp in the receiver
CC domain of the RR protein.
CC -!- SIMILARITY: Belongs to the ARR family. Type-A subfamily. {ECO:0000305}.
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DR EMBL; AB010917; BAA31145.1; -; mRNA.
DR EMBL; AC005662; AAC78541.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09959.1; -; Genomic_DNA.
DR EMBL; AY074643; AAL69459.1; -; mRNA.
DR PIR; T48853; T48853.
DR RefSeq; NP_181663.1; NM_129695.4.
DR AlphaFoldDB; O80365; -.
DR SMR; O80365; -.
DR BioGRID; 4067; 8.
DR IntAct; O80365; 9.
DR STRING; 3702.AT2G41310.1; -.
DR PaxDb; O80365; -.
DR PRIDE; O80365; -.
DR ProteomicsDB; 246903; -.
DR EnsemblPlants; AT2G41310.1; AT2G41310.1; AT2G41310.
DR GeneID; 818730; -.
DR Gramene; AT2G41310.1; AT2G41310.1; AT2G41310.
DR KEGG; ath:AT2G41310; -.
DR Araport; AT2G41310; -.
DR TAIR; locus:2040282; AT2G41310.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_000445_69_5_1; -.
DR InParanoid; O80365; -.
DR OMA; ERTGTIY; -.
DR OrthoDB; 1297681at2759; -.
DR PhylomeDB; O80365; -.
DR PRO; PR:O80365; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O80365; baseline and differential.
DR Genevisible; O80365; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0000156; F:phosphorelay response regulator activity; ISS:TAIR.
DR GO; GO:0007623; P:circadian rhythm; IMP:TAIR.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IMP:TAIR.
DR GO; GO:0000160; P:phosphorelay signal transduction system; ISS:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR InterPro; IPR045279; ARR-like.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43874; PTHR43874; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Cytokinin signaling pathway; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..225
FT /note="Two-component response regulator ARR8"
FT /id="PRO_0000081429"
FT DOMAIN 10..145
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT MOD_RES 78
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 225 AA; 25471 MW; 46F9661CDD19C534 CRC64;
MVMETESKFH VLAVDDSLFD RKMIERLLQK SSCQVTTVDS GSKALEFLGL RVDDNDPNAL
STSPQIHQEV EINLIITDYC MPGMTGYDLL KKVKESAAFR SIPVVIMSSE NVPARISRCL
EEGAEEFFLK PVKLADLTKL KPHMMKTKLK KESEKPVAIE EIVVSKPEIE EEEEESSVIE
ILPLHQEIES EQLEPMLSSN KRKAMEEVVS TDRSRPKYND ITTSV
