O2A12_HUMAN
ID O2A12_HUMAN Reviewed; 310 AA.
AC Q8NGT7; A4D2G4; Q6IF43;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Olfactory receptor 2A12;
DE AltName: Full=Olfactory receptor OR7-10;
GN Name=OR2A12; Synonyms=OR2A12P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=25977809; DOI=10.1038/sdata.2015.2;
RA Mainland J.D., Li Y.R., Zhou T., Liu W.L., Matsunami H.;
RT "Human olfactory receptor responses to odorants.";
RL Sci. Data 2:150002-150002(2015).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [7]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2A12";
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DR EMBL; AB065694; BAC05917.1; -; Genomic_DNA.
DR EMBL; KP290177; ALI87363.1; -; Genomic_DNA.
DR EMBL; CH236959; EAL23798.1; -; Genomic_DNA.
DR EMBL; CH878732; EAW55631.1; -; Genomic_DNA.
DR EMBL; BC136902; AAI36903.1; -; mRNA.
DR EMBL; BC136903; AAI36904.1; -; mRNA.
DR EMBL; BK004419; DAA04817.1; -; Genomic_DNA.
DR CCDS; CCDS43670.1; -.
DR RefSeq; NP_001004135.1; NM_001004135.1.
DR AlphaFoldDB; Q8NGT7; -.
DR SMR; Q8NGT7; -.
DR BioGRID; 131386; 3.
DR STRING; 9606.ENSP00000386174; -.
DR GlyGen; Q8NGT7; 1 site.
DR iPTMnet; Q8NGT7; -.
DR PhosphoSitePlus; Q8NGT7; -.
DR BioMuta; OR2A12; -.
DR DMDM; 38372499; -.
DR MassIVE; Q8NGT7; -.
DR PaxDb; Q8NGT7; -.
DR PeptideAtlas; Q8NGT7; -.
DR PRIDE; Q8NGT7; -.
DR ProteomicsDB; 73601; -.
DR Antibodypedia; 67812; 74 antibodies from 19 providers.
DR DNASU; 346525; -.
DR Ensembl; ENST00000408949.2; ENSP00000386174.2; ENSG00000221858.3.
DR Ensembl; ENST00000641592.1; ENSP00000493157.1; ENSG00000221858.3.
DR GeneID; 346525; -.
DR KEGG; hsa:346525; -.
DR MANE-Select; ENST00000641592.1; ENSP00000493157.1; NM_001004135.2; NP_001004135.1.
DR UCSC; uc011kty.3; human.
DR CTD; 346525; -.
DR GeneCards; OR2A12; -.
DR HGNC; HGNC:15082; OR2A12.
DR HPA; ENSG00000221858; Not detected.
DR neXtProt; NX_Q8NGT7; -.
DR PharmGKB; PA32104; -.
DR VEuPathDB; HostDB:ENSG00000221858; -.
DR eggNOG; ENOG502SIA2; Eukaryota.
DR GeneTree; ENSGT00940000153255; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NGT7; -.
DR OMA; LAVTECM; -.
DR OrthoDB; 1018653at2759; -.
DR PhylomeDB; Q8NGT7; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGT7; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 346525; 9 hits in 668 CRISPR screens.
DR ChiTaRS; OR2A12; human.
DR GeneWiki; OR2A12; -.
DR GenomeRNAi; 346525; -.
DR Pharos; Q8NGT7; Tdark.
DR PRO; PR:Q8NGT7; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8NGT7; protein.
DR Bgee; ENSG00000221858; Expressed in reproductive system and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 2A12"
FT /id="PRO_0000150457"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 223
FT /note="A -> T (in dbSNP:rs9655672)"
FT /id="VAR_034171"
SQ SEQUENCE 310 AA; 35213 MW; 5A25409ADB5BC857 CRC64;
MESNQTWITE VILLGFQVDP ALELFLFGFF LLFYSLTLMG NGIILGLIYL DSRLHTPMYV
FLSHLAIVDM SYASSTVPKM LANLVMHKKV ISFAPCILQT FLYLAFAITE CLILVMMCYD
RYVAICHPLQ YTLIMNWRVC TVLASTCWIF SFLLALVHIT LILRLPFCGP QKINHFFCQI
MSVFKLACAD TRLNQVVLFA GSAFILVGPL CLVLVSYLHI LVAILRIQSG EGRRKAFSTC
SSHLCVVGLF FGSAIVMYMA PKSSHSQERR KILSLFYSLF NPILNPLIYS LRNAEVKGAL
KRVLWKQRSM
