O2AE1_HUMAN
ID O2AE1_HUMAN Reviewed; 323 AA.
AC Q8NHA4; B2RPD2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Olfactory receptor 2AE1;
DE AltName: Full=Olfactory receptor 2AE2;
GN Name=OR2AE1; Synonyms=OR2AE2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2AE1";
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DR EMBL; AB065478; BAC05732.1; -; Genomic_DNA.
DR EMBL; BC137375; AAI37376.1; -; mRNA.
DR EMBL; BC137376; AAI37377.1; -; mRNA.
DR CCDS; CCDS34696.1; -.
DR RefSeq; NP_001005276.1; NM_001005276.1.
DR AlphaFoldDB; Q8NHA4; -.
DR SMR; Q8NHA4; -.
DR BioGRID; 123471; 1.
DR IntAct; Q8NHA4; 1.
DR STRING; 9606.ENSP00000313936; -.
DR GlyGen; Q8NHA4; 1 site.
DR BioMuta; OR2AE1; -.
DR DMDM; 38372832; -.
DR MassIVE; Q8NHA4; -.
DR PaxDb; Q8NHA4; -.
DR PeptideAtlas; Q8NHA4; -.
DR PRIDE; Q8NHA4; -.
DR Antibodypedia; 49775; 34 antibodies from 17 providers.
DR DNASU; 81392; -.
DR Ensembl; ENST00000316368.3; ENSP00000313936.2; ENSG00000244623.2.
DR GeneID; 81392; -.
DR KEGG; hsa:81392; -.
DR MANE-Select; ENST00000316368.3; ENSP00000313936.2; NM_001005276.1; NP_001005276.1.
DR UCSC; uc003usc.2; human.
DR CTD; 81392; -.
DR GeneCards; OR2AE1; -.
DR HGNC; HGNC:15087; OR2AE1.
DR HPA; ENSG00000244623; Not detected.
DR neXtProt; NX_Q8NHA4; -.
DR PharmGKB; PA32123; -.
DR VEuPathDB; HostDB:ENSG00000244623; -.
DR eggNOG; ENOG502T9MF; Eukaryota.
DR GeneTree; ENSGT01050000244880; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q8NHA4; -.
DR OMA; IVVSFWF; -.
DR OrthoDB; 955793at2759; -.
DR PhylomeDB; Q8NHA4; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NHA4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81392; 11 hits in 665 CRISPR screens.
DR GeneWiki; OR2AE1; -.
DR GenomeRNAi; 81392; -.
DR Pharos; Q8NHA4; Tdark.
DR PRO; PR:Q8NHA4; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8NHA4; protein.
DR Bgee; ENSG00000244623; Expressed in right coronary artery and 28 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..323
FT /note="Olfactory receptor 2AE1"
FT /id="PRO_0000150471"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..323
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 77
FT /note="I -> T (in dbSNP:rs2572023)"
FT /id="VAR_053138"
FT VARIANT 217
FT /note="Y -> C (in dbSNP:rs60737583)"
FT /id="VAR_062019"
FT VARIANT 267
FT /note="L -> V (in dbSNP:rs17161997)"
FT /id="VAR_053139"
SQ SEQUENCE 323 AA; 36588 MW; A74B4E9D9F41C434 CRC64;
MWQKNQTSLA DFILEGLFDD SLTHLFLFSL TMVVFLIAVS GNTLTILLIC IDPQLHTPMY
FLLSQLSLMD LMHVSTIILK MATNYLSGKK SISFVGCATQ HFLYLCLGGA ECFLLAVMSY
DRYVAICHPL RYAVLMNKKV GLMMAVMSWL GASVNSLIHM AILMHFPFCG PRKVYHFYCE
FPAVVKLVCG DITVYETTVY ISSILLLLPI FLISTSYVFI LQSVIQMRSS GSKRNAFATC
GSHLTVVSLW FGACIFSYMR PRSQCTLLQN KVGSVFYSII TPTLNSLIYT LRNKDVAKAL
RRVLRRDVIT QCIQRLQLWL PRV
