O2AG2_HUMAN
ID O2AG2_HUMAN Reviewed; 316 AA.
AC A6NM03; B9EIM0;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Olfactory receptor 2AG2;
GN Name=OR2AG2; Synonyms=OR2AG2P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS CYS-28 AND PRO-54.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2AG2";
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DR EMBL; AC091564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC140734; AAI40735.1; -; mRNA.
DR CCDS; CCDS31413.1; -.
DR RefSeq; NP_001004490.1; NM_001004490.1.
DR AlphaFoldDB; A6NM03; -.
DR SMR; A6NM03; -.
DR STRING; 9606.ENSP00000342697; -.
DR GlyGen; A6NM03; 2 sites.
DR iPTMnet; A6NM03; -.
DR PhosphoSitePlus; A6NM03; -.
DR BioMuta; OR2AG2; -.
DR MassIVE; A6NM03; -.
DR PaxDb; A6NM03; -.
DR PeptideAtlas; A6NM03; -.
DR PRIDE; A6NM03; -.
DR Antibodypedia; 23952; 76 antibodies from 20 providers.
DR DNASU; 338755; -.
DR Ensembl; ENST00000641124.1; ENSP00000493362.1; ENSG00000188124.4.
DR Ensembl; ENST00000641169.1; ENSP00000493311.1; ENSG00000188124.4.
DR GeneID; 338755; -.
DR KEGG; hsa:338755; -.
DR MANE-Select; ENST00000641124.1; ENSP00000493362.1; NM_001004490.2; NP_001004490.1.
DR UCSC; uc001meq.2; human.
DR CTD; 338755; -.
DR GeneCards; OR2AG2; -.
DR HGNC; HGNC:15143; OR2AG2.
DR HPA; ENSG00000188124; Not detected.
DR neXtProt; NX_A6NM03; -.
DR OpenTargets; ENSG00000188124; -.
DR PharmGKB; PA32127; -.
DR VEuPathDB; HostDB:ENSG00000188124; -.
DR eggNOG; ENOG502SIEP; Eukaryota.
DR GeneTree; ENSGT01050000244880; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; A6NM03; -.
DR OMA; CMSWEIR; -.
DR OrthoDB; 951071at2759; -.
DR PhylomeDB; A6NM03; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; A6NM03; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 338755; 10 hits in 677 CRISPR screens.
DR ChiTaRS; OR2AG2; human.
DR GenomeRNAi; 338755; -.
DR Pharos; A6NM03; Tdark.
DR PRO; PR:A6NM03; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; A6NM03; protein.
DR Bgee; ENSG00000188124; Expressed in prefrontal cortex and 13 other tissues.
DR ExpressionAtlas; A6NM03; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 2AG2"
FT /id="PRO_0000312343"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 28
FT /note="Y -> C (in dbSNP:rs7102536)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037497"
FT VARIANT 54
FT /note="R -> P (in dbSNP:rs10839616)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037498"
FT VARIANT 87
FT /note="R -> L (in dbSNP:rs11828782)"
FT /id="VAR_037499"
FT VARIANT 299
FT /note="R -> G (in dbSNP:rs7924459)"
FT /id="VAR_037500"
SQ SEQUENCE 316 AA; 35270 MW; 0B2E3D549FEB7FF1 CRC64;
MELRNSTLGS GFILVGILND SGSPELLYAT FTILYMLALT SNGLLLLAIT IEARLHMPMY
LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ MFLALTMGSA EDLLLAFMAY
DRYVAICHPL KYMTLMSPRV CWIMVATSWI LASLIAIGHT MYTMHLPFCV SWEIRHLLCE
IPPLLKLACA DTSRYELIIY VTGVTFLLLP ISAIVASYTL VLFTVLRMPS NEGRKKALVT
CSSHLIVVGM FYGAATFMYV LPSSFHSPKQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA
LRRVLGKYIL LAHSTL
