O2AJ1_HUMAN
ID O2AJ1_HUMAN Reviewed; 328 AA.
AC Q8NGZ0;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Olfactory receptor 2AJ1;
GN Name=OR2AJ1; Synonyms=OR2AJ1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2AJ1";
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DR EMBL; AB065626; BAC05852.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8NGZ0; -.
DR SMR; Q8NGZ0; -.
DR IntAct; Q8NGZ0; 1.
DR STRING; 9606.ENSP00000325078; -.
DR GlyGen; Q8NGZ0; 1 site.
DR BioMuta; OR2AJ1; -.
DR DMDM; 74762585; -.
DR MassIVE; Q8NGZ0; -.
DR PaxDb; Q8NGZ0; -.
DR PRIDE; Q8NGZ0; -.
DR Antibodypedia; 71732; 15 antibodies from 10 providers.
DR Ensembl; ENST00000318244.4; ENSP00000325078.3; ENSG00000177275.4.
DR MANE-Select; ENST00000318244.4; ENSP00000325078.3; NM_001355235.2; NP_001342164.2.
DR UCSC; uc057raw.1; human.
DR GeneCards; OR2AJ1; -.
DR HGNC; HGNC:15001; OR2AJ1.
DR HPA; ENSG00000177275; Not detected.
DR neXtProt; NX_Q8NGZ0; -.
DR VEuPathDB; HostDB:ENSG00000177275; -.
DR eggNOG; ENOG502RTYN; Eukaryota.
DR GeneTree; ENSGT01050000244880; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NGZ0; -.
DR OMA; FIMSVTE; -.
DR PhylomeDB; Q8NGZ0; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NGZ0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGZ0; -.
DR Pharos; Q8NGZ0; Tdark.
DR PRO; PR:Q8NGZ0; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGZ0; protein.
DR Bgee; ENSG00000177275; Expressed in superior frontal gyrus and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR InterPro; IPR030788; OR2AJ1.
DR PANTHER; PTHR26453:SF214; PTHR26453:SF214; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..328
FT /note="Olfactory receptor 2AJ1"
FT /id="PRO_0000150473"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..328
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 328 AA; 37063 MW; FCE591F900640DBB CRC64;
MGHQNHTFSS DFILLGLFSS SPTSVVFFLV LFVIFIMSVT ENTLMILLIR SDSRLHTPMY
FLLSHLSLMD ILHVSNIVPK MVTNFLSGSR TISFAGCGFQ VFLSLTLLGG ECLLLAAMSC
DRYVAICHPL RYPILMKEYA SALMAGGSWL IGVFNSTVHT AYALQFPFCG SRAIDHFFCE
VPAMLKLSCA DTTRYERGVC VSAVIFLLIP FSLISASYGQ IILTVLQMKS SEARKKSFST
CSFHMIVVTM YYGPFIFTYM RPKSYHTPGQ DKFLAIFYTI LTPTLNPFIY SFRNKDVLAV
MKNMLKSNFL HKKMNRKIPE CVFCLFLC
