O2AK2_HUMAN
ID O2AK2_HUMAN Reviewed; 335 AA.
AC Q8NG84; B2RND1; Q6IF05;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Olfactory receptor 2AK2;
DE AltName: Full=Olfactory receptor 2AK1;
DE AltName: Full=Olfactory receptor OR1-47;
GN Name=OR2AK2; Synonyms=OR2AK1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-203.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-16 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC06164.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2AK2";
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DR EMBL; AB065951; BAC06164.1; ALT_INIT; Genomic_DNA.
DR EMBL; AC099570; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136816; AAI36817.1; -; mRNA.
DR EMBL; BK004457; DAA04855.1; -; Genomic_DNA.
DR RefSeq; NP_001004491.1; NM_001004491.1.
DR AlphaFoldDB; Q8NG84; -.
DR SMR; Q8NG84; -.
DR STRING; 9606.ENSP00000355436; -.
DR GlyGen; Q8NG84; 1 site.
DR iPTMnet; Q8NG84; -.
DR PhosphoSitePlus; Q8NG84; -.
DR BioMuta; OR2AK2; -.
DR DMDM; 229462914; -.
DR MassIVE; Q8NG84; -.
DR PaxDb; Q8NG84; -.
DR PeptideAtlas; Q8NG84; -.
DR PRIDE; Q8NG84; -.
DR ProteomicsDB; 73450; -.
DR DNASU; 391191; -.
DR GeneID; 391191; -.
DR KEGG; hsa:391191; -.
DR UCSC; uc010pzd.3; human.
DR CTD; 391191; -.
DR GeneCards; OR2AK2; -.
DR HGNC; HGNC:19569; OR2AK2.
DR neXtProt; NX_Q8NG84; -.
DR PharmGKB; PA134921949; -.
DR eggNOG; ENOG502RTYI; Eukaryota.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8NG84; -.
DR OrthoDB; 987071at2759; -.
DR PhylomeDB; Q8NG84; -.
DR TreeFam; TF337295; -.
DR PathwayCommons; Q8NG84; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 391191; 11 hits in 675 CRISPR screens.
DR GeneWiki; OR2AK2; -.
DR GenomeRNAi; 391191; -.
DR Pharos; Q8NG84; Tdark.
DR PRO; PR:Q8NG84; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8NG84; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..335
FT /note="Olfactory receptor 2AK2"
FT /id="PRO_0000150474"
FT TOPO_DOM 1..40
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..94
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..115
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..135
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..173
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..210
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..234
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..274
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..307
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..335
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 112..204
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 99
FT /note="S -> N (in dbSNP:rs6664332)"
FT /id="VAR_055051"
FT VARIANT 203
FT /note="V -> M (in dbSNP:rs4478844)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055052"
SQ SEQUENCE 335 AA; 37763 MW; 663745628F070E7F CRC64;
MNISDVISFD ILVSAMKTGN QSFGTDFLLV GLFQYGWINS LLFVVIATLF TVALTGNIML
IHLIRLNTRL HTPMYFLLSQ LSIVDLMYIS TTVPKMAVSF LSQSKTIRFL GCEIQTYVFL
ALGGTEALLL GFMSYDRYVA ICHPLHYPML MSKKICCLMV ACAWASGSIN AFIHTLYVFQ
LPFCRSRLIN HFFCEVPALL SLVCQDTSQY EYTVLLSGLI ILLLPFLAIL ASYARVLIVV
FQMSSGKGQA KAVSTCSSHL IVASLFYATT LFTYTRPHSL RSPSRDKAVA VFYTIVTPLL
NPFIYSLRNK EVTGAVRRLL GYWICCRKYD FRSLY
