O2AP1_HUMAN
ID O2AP1_HUMAN Reviewed; 309 AA.
AC Q8NGE2;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Olfactory receptor 2AP1;
DE AltName: Full=Olfactory receptor OR12-9;
GN Name=OR2AP1; Synonyms=OR2AP1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2AP1";
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DR EMBL; AB065868; BAC06086.1; -; Genomic_DNA.
DR EMBL; BK004260; DAA04658.1; -; Genomic_DNA.
DR CCDS; CCDS58241.1; -.
DR RefSeq; NP_001245214.1; NM_001258285.1.
DR AlphaFoldDB; Q8NGE2; -.
DR SMR; Q8NGE2; -.
DR STRING; 9606.ENSP00000323423; -.
DR GlyGen; Q8NGE2; 2 sites.
DR BioMuta; OR2AP1; -.
DR DMDM; 74760248; -.
DR jPOST; Q8NGE2; -.
DR MassIVE; Q8NGE2; -.
DR PaxDb; Q8NGE2; -.
DR PeptideAtlas; Q8NGE2; -.
DR PRIDE; Q8NGE2; -.
DR Antibodypedia; 63427; 37 antibodies from 15 providers.
DR DNASU; 121129; -.
DR Ensembl; ENST00000641114.1; ENSP00000493043.1; ENSG00000179615.3.
DR GeneID; 121129; -.
DR KEGG; hsa:121129; -.
DR MANE-Select; ENST00000641114.1; ENSP00000493043.1; NM_001258285.2; NP_001245214.1.
DR UCSC; uc031qhr.1; human.
DR CTD; 121129; -.
DR GeneCards; OR2AP1; -.
DR HGNC; HGNC:15335; OR2AP1.
DR HPA; ENSG00000179615; Not detected.
DR neXtProt; NX_Q8NGE2; -.
DR OpenTargets; ENSG00000179615; -.
DR VEuPathDB; HostDB:ENSG00000179615; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01040000240425; -.
DR HOGENOM; CLU_012526_1_1_1; -.
DR InParanoid; Q8NGE2; -.
DR OMA; GTFNKGV; -.
DR OrthoDB; 1171161at2759; -.
DR PhylomeDB; Q8NGE2; -.
DR TreeFam; TF336833; -.
DR PathwayCommons; Q8NGE2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 121129; 5 hits in 665 CRISPR screens.
DR GeneWiki; OR2AP1; -.
DR GenomeRNAi; 121129; -.
DR Pharos; Q8NGE2; Tdark.
DR PRO; PR:Q8NGE2; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8NGE2; protein.
DR ExpressionAtlas; Q8NGE2; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 2AP1"
FT /id="PRO_0000150475"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 309 AA; 34902 MW; 0BD7AFFEA740CA12 CRC64;
MKNKTVLTEF ILLGLTDVPE LQVAVFTFLF LAYLLSILGN LTILILTLLD SHLQTPMYFF
LRNFSFLEIS FTNIFIPRVL ISITTGNKSI SFAGCFTQYF FAMFLGATEF YLLAAMSYDR
YVAICKPLHY TTIMSSRICI QLIFCSWLGG LMAIIPTITL MSQQDFCASN RLNHYFCDYE
PLLELSCSDT SLIEKVVFLV ASVTLVVTLV LVILSYAFII KTILKLPSAQ QRTKAFSTCS
SHMIVISLSY GSCMFMYINP SAKEGDTFNK GVALLITSVA PLLNPFIYTL RNQQVKQPFK
DMVKKLLNL
