ARR9_ARATH
ID ARR9_ARATH Reviewed; 234 AA.
AC O80366;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Two-component response regulator ARR9;
DE AltName: Full=Response reactor 4;
GN Name=ARR9; Synonyms=ATRR4; OrderedLocusNames=At3g57040; ORFNames=F24I3.120;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=9607306; DOI=10.1016/s0014-5793(98)00418-9;
RA Urao T., Yakubov B., Yamaguchi-Shinozaki K., Shinozaki K.;
RT "Stress-responsive expression of genes for two-component response
RT regulator-like proteins in Arabidopsis thaliana.";
RL FEBS Lett. 427:175-178(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP INTERACTION WITH AHP1 AND AHP3.
RX PubMed=10930573; DOI=10.1016/s0014-5793(00)01860-3;
RA Urao T., Miyata S., Yamaguchi-Shinozaki K., Shinozaki K.;
RT "Possible His to Asp phosphorelay signaling in an Arabidopsis two-component
RT system.";
RL FEBS Lett. 478:227-232(2000).
RN [6]
RP FUNCTION.
RX PubMed=14973166; DOI=10.1105/tpc.018978;
RA To J.P.C., Haberer G., Ferreira F.J., Deruere J., Mason M.G.,
RA Schaller G.E., Alonso J.M., Ecker J.R., Kieber J.J.;
RT "Type-A Arabidopsis response regulators are partially redundant negative
RT regulators of cytokinin signaling.";
RL Plant Cell 16:658-671(2004).
CC -!- FUNCTION: Functions as response regulator involved in His-to-Asp
CC phosphorelay signal transduction system. Phosphorylation of the Asp
CC residue in the receiver domain activates the ability of the protein to
CC promote the transcription of target genes. Type-A response regulators
CC seem to act as negative regulators of the cytokinin signaling.
CC {ECO:0000269|PubMed:14973166}.
CC -!- SUBUNIT: Interacts with AHP1 and AHP3. {ECO:0000269|PubMed:10930573}.
CC -!- INTERACTION:
CC O80366; Q9ZNV9: AHP1; NbExp=3; IntAct=EBI-1100950, EBI-1100673;
CC O80366; Q9ZNV8: AHP2; NbExp=4; IntAct=EBI-1100950, EBI-1100687;
CC O80366; Q9SAZ5: AHP3; NbExp=5; IntAct=EBI-1100950, EBI-1100711;
CC O80366; Q67XQ1: At1g03430; NbExp=3; IntAct=EBI-1100950, EBI-1100725;
CC O80366; Q9C9L2: TCP15; NbExp=3; IntAct=EBI-1100950, EBI-4426144;
CC O80366; Q9LQF0: TCP23; NbExp=3; IntAct=EBI-1100950, EBI-15192297;
CC O80366; Q9MAH8: TCP3; NbExp=3; IntAct=EBI-1100950, EBI-25522447;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in roots.
CC {ECO:0000269|PubMed:9607306}.
CC -!- PTM: Two-component system major event consists of a His-to-Asp
CC phosphorelay between a sensor histidine kinase (HK) and a response
CC regulator (RR). In plants, the His-to-Asp phosphorelay involves an
CC additional intermediate named Histidine-containing phosphotransfer
CC protein (HPt). This multistep phosphorelay consists of a His-Asp-His-
CC Asp sequential transfer of a phosphate group between first an His and
CC an Asp of the HK protein, followed by the transfer to a conserved His
CC of the HPt protein and finally the transfer to an Asp in the receiver
CC domain of the RR protein.
CC -!- SIMILARITY: Belongs to the ARR family. Type-A subfamily. {ECO:0000305}.
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DR EMBL; AB010918; BAA31146.1; -; mRNA.
DR EMBL; AL138655; CAB72174.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79602.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM63540.1; -; Genomic_DNA.
DR EMBL; AY090234; AAL90898.1; -; mRNA.
DR EMBL; AY133571; AAM91401.1; -; mRNA.
DR PIR; T47764; T47764.
DR RefSeq; NP_001325622.1; NM_001339837.1.
DR RefSeq; NP_191263.1; NM_115563.3.
DR AlphaFoldDB; O80366; -.
DR SMR; O80366; -.
DR BioGRID; 10187; 10.
DR IntAct; O80366; 11.
DR STRING; 3702.AT3G57040.1; -.
DR PaxDb; O80366; -.
DR PRIDE; O80366; -.
DR ProteomicsDB; 246674; -.
DR EnsemblPlants; AT3G57040.1; AT3G57040.1; AT3G57040.
DR EnsemblPlants; AT3G57040.2; AT3G57040.2; AT3G57040.
DR GeneID; 824871; -.
DR Gramene; AT3G57040.1; AT3G57040.1; AT3G57040.
DR Gramene; AT3G57040.2; AT3G57040.2; AT3G57040.
DR KEGG; ath:AT3G57040; -.
DR Araport; AT3G57040; -.
DR TAIR; locus:2080590; AT3G57040.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_000445_69_5_1; -.
DR InParanoid; O80366; -.
DR OMA; IANISSX; -.
DR OrthoDB; 1297681at2759; -.
DR PhylomeDB; O80366; -.
DR PRO; PR:O80366; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; O80366; baseline and differential.
DR Genevisible; O80366; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0000156; F:phosphorelay response regulator activity; ISS:TAIR.
DR GO; GO:0007623; P:circadian rhythm; IMP:TAIR.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IMP:TAIR.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IPI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0009735; P:response to cytokinin; IEP:TAIR.
DR InterPro; IPR045279; ARR-like.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43874; PTHR43874; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Cytokinin signaling pathway; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..234
FT /note="Two-component response regulator ARR9"
FT /id="PRO_0000081430"
FT DOMAIN 10..147
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT MOD_RES 80
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 234 AA; 26089 MW; 489D89364F8585FC CRC64;
MGMAAESQFH VLAVDDSLFD RKLIERLLQK SSCQVTTVDS GSKALEFLGL RQSTDSNDPN
AFSKAPVNHQ VVEVNLIITD YCMPGMTGYD LLKKVKESSA FRDIPVVIMS SENVPARISR
CLEEGAEEFF LKPVRLADLN KLKPHMMKTK LKNQKLEEIE TTSKVENGVP TAVADPEIKD
STNIEIEILP LQQDLLLVQQ EEQTLSINNK RKSVEEGIST DRARPRFDGI ATAV
